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Full Description
This book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo, environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis.The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.
Contents
Alpha Cell Contribution to Glucose Homeostasis.- Delta Cell Contribution to Glucose Homeostasis.- Islet Cell Plasticity Including Beta-Cell Dedifferentiation—Combined with Beta-Cell Heterogeneity.- Epigenetic Regulation of Pancreas Development and Function.- Beta-Cell Differentiation in vitro.- Endocrine Pancreas Regeneration.- Ductal Cell Development.- Relationship Between Beta-Cell Function and Beta-Cell Proliferation.- Maternal and Paternal Environmental Impacts on Beta-Cell Development.- Beyond Sugar: How Fat and Protein Contribute to the Regulation of Insulin Secretion.- Channels Involved in Regulating Insulin Secretion.