Full Description
Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases.
The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed.
The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer.
Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer.
Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.
Contents
Part 1: Regulation Of Key Metabolic Pathways In Cancer.- Chapter 1: Reprogramming Carbohydrate Metabolism In Cancer And Its Role In Regulating The Tumor Microenvironment. Chapter 2: Iron In Cancer Progression: Does Bach1 Promote Metastasis By Altering Iron Homeostasis?.- Chapter 3: Regulation Of Lipid Metabolism Under Stress And Its Role In Cancer.- Chapter 4: Role Of The Histone Acetyl Transferase Mof And The Histone Deacetylase Sirtuins In Regulation Of H4k16ac During Dna Damage Repair And Metabolic Programming: Implications In Cancer And Aging.- Chapter 5: Autophagy In Cancer: A Metabolic Perspective.- Part 2: Epigenetic Regulation Of Cellular Metabolic Pathways.- Chapter 6: Long Noncoding Rnas; Lnc(Ing) Rna Metabolism, To Cancer Biology.- Chapter 7: Modulation Of Dna/Rna Methylation Signalling Mediating Metabolic Homeostasis In Cancer.- Chapter 8: Nutritional Epigenetics: How Metabolism Epigenetically Controls Cellular Physiology, Gene Expression And Disease.- Chapter 9: Epigenetic Reprogramming Of The Glucose Metabolic Pathways By The Chromatin Effectors During Cancer.- Chapter 10: Sirtuin 6 Is A Critical Epigenetic Regulator Of Cancer.- Chapter 11: Epigenetic Regulation During Hypoxia And Its Implications In Cancer.- Part 3: Epigenetic Regulation In Cancer.- Chapter 12: Metabolic Regulation Of Lysine Acetylation: Implications In Cancer.- Chapter 13: The Cross-Talk Between Epigenetic Gene Regulation And Signaling Pathways Regulates Cancer Pathogenesis.- Chapter 14: Epigenetic Regulation Towards Acquired Drug Resistance In Cancer.- Chapter 15: Structural Basis Of Targeted Imaging And Therapy In Cancer- Explorations With The Epigenetic Drugs.- Chapter 16: Epigenetic Small Molecule Modulators Targeting Metabolic Pathways In Cancer.- Chapter 17: Modulation Of Dna/Rna Methylation By Small Molecule Modulators And Their Implications In Cancer.- Chapter 18: Understanding The Cross-Talk Between Epigenetics And Immunometabolism To Combat Cancer.
