The ADME Encyclopedia : A Comprehensive Guide on Biopharmacy and Pharmacokinetics （1st ed. 2022. 2022. x, 1190 S. X, 1190 p. 200 illus., 100 illus. in co）

Herausgegeben:Talevi, Alan

SPRINGER, BERLIN; SPRINGER INTERNATIONAL PUBLISHING;（2022発売）

• 商品コード 9783030848613

Full Description

The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry).Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties

Contents

Drug dissolution and drug releaseMathematical models of drug dissolution and drug releaseDiffusion layer modelDanckwert's modelInterfacial barrier model First order modelHiguchi modelKorsmeyer-Peppas modelHixson-Crowell modelBaker-Lonsdale model Weibull model In vitro dissolution testingModalities of dissolution testsBiorelevant dissolution mediaDrug absorptionFree diffusionFacilitated diffusionActive transport Transcytosis pH partition theorypKa determinationFactors impacting drug absorptionDrug distributionFactors impacting drug distributionReal volume of distributionApparent volume of distribution Drug binding to plasma proteinsDrug displacement Non-linear binding to plasma proteins Drug binding to tissue componentsOne-compartment pharmacokinetic modelTwo-compartment pharmacokinetic modelCentral nervous system bioavailabilityBlood-brain barrierlog BB KpuuDrug metabolismFunctionalization reactionsSynthetic reactionsCytochrome P450Phase III reactionsFactors impacting on drug metabolismGenetic variants. PolymorphismAgeGenderEnvironmental factors: enzyme induction Precision medicinePharmacogenomic DNA chips MicrosomesDrug excretionBiliary excretionEnterohepatic recycling Enterohepatic recycling and antibioticsRenal excretionGlomerular filtrationTubular reabsorptionTubular secretionClearanceOrgan clearance Routes of administration Oral routeMigrating motor complexEnteric coating tablets Food-drug interactions Gastric emptying Gastroretentive drug delivery systemsMultiparticulate drug delivery systems Gut microbiota Lipinski rule of five Permeation enhancersIntestinal perfusion modelsBucal and sublingual route Rectal route Intravenous route Intravenous bolusIntravenous infusionTechnological considerations for intravenous administrationIntramuscular administration Subcutaneous administration Specialized parenteral routesPulmonary administrationNasal administrationTransdermal administrationPermeation enhancersNext generation drug delivery systemsNanocarriers Surface-to-volume ratioSurface chemistryNanotoxicologyDrug release from nanocarriersPassive targetingSmart systems / stimuli-responsive systems Active targeting Mononuclear phagocyte systemAbsorption and distribution of nanocarriersElimination of nanocarriersPEGylationADMEViral vectors PharmacogenomicsEnzyme polymorphismTransporter polymorphism Pharmacogenomics and pediatricsBioavailability and bioequivalence BioavailabilitySystemic bioavailabilityGeneric drugsPost-approval changesBioequivalenceAbsolute bioavailabilityMass balance studiesBioequivalence studiesReference and test productsBiopharmaceutical Classification System BiowaiversBCS subclasses Dissolution testingPharmacodynamic studiesBiopharmaceutical drug productsAbsorption of protein drugsDistribution of protein drugs Elimination of protein drugsADME properties of insulinsADME properties of heparins ADME properties of gene-based biopharmaceuticals Drug-drug and food-drug interactions Plasma protein binding DDIMembrane transport DDIMetabolism DDIFDI based on induction of gastrointestinal changesIn vitro and in silico ADME predictionsPolarized cell linesCaco-2MDCK SolubilityDissolution testingQSPR/QSARExpert rulesCentral Nervous System Multiparameter Optimization Dynamic transit modelsSandwich-cultured hepatocytesSingle-cell expression systemsMembrane vesiclesMolecular dynamics simulationsDrug tansportersABC transportersMDR1 MRPsBCRPSolute carriersOrganic anion transportersOrganic cation transporters Peptide transportersNon-linear pharmacokineticsLinear pharmacokinetics Positive deviations from linear behaviorNegative deviations from linear behaviorTime-dependent pharmacokineticsPharmacometrics and physiologic models