Full Description
This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice.
Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control.
Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy.
Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum. Featuring cross-disciplinary authorship, this work further contributes to advances in comparative medicine and translation research in support of the One Health concept.
Contents
Part 1: Technology and Science of Electroporation: Fundamentals.- Electroporation: Technology and Science.- Electrodes and electric field distribution in clinical practice.- Part 2: Therapeutic Applications with Electroporation in Veterinary Oncology Practice.- Electrochemotherapy in Veterinary Oncology.- Treating Mast Cell Tumors with Electrochemotherapy.- Electrochemotherapy for the treatment of transitional cell carcinoma in dogs.- Calcium electroporation in veterinary medicine.- Irreversible Electroporation Applications.- Electrochemotherapy as a multi-modality component of cancer treatment- combinations with surgery, radiation therapy and chemotherapy.- Part 3: Gene-Electrotransfer and Immunotherapy Applications with Electroporation.- Gene Electrotransfer.- Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer.- Interleukin-12 gene electrotransfer in veterinary oncology.- Canine Melanoma and Osteosarcoma Immunotherapy by means of in vivo DNA Electroporation.-Part 4: Evolution of the Field and New Applications with Electroporation-Based Treatments: Outlook.- Electrodes for Unique Anatomical Access in Electroporation.- New Electrodes and Treatment Planning for deep-seated and intraluminal localized tumors.- Advancing Electroporation Systems.
