Full Description
Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer's and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials.
This second, companion volume will provide a comprehensive overview of Par-4's role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
Contents
Introduction. --Part 1.- Chapter 1. Role of Par-4 in lung cancer.- Chapter 2. Prostate apoptosis response-4 in nasopharyngeal carcinoma.- Chapter 3. Role of Par-4 in Chemoresistance and targeted therapies in ovarian and endometrial cancers.- Chapter 4. Regulation of Par-4 and role in GI tumors.- Chapter 5. Role of Par-4 in prostate cancer.- Chapter 6. Activation of apoptosis by Par-4 in pancreatic cancer.- Chapter 7. Role of Par-4 and GRP78 in Glioblastoma.- Chapter 8. Role of Par-4 in breast cancer recurrence.- Chapter 9. Involvement of Par-4 in breast cancer.- Chapter 10. Role of endogenous Par-4 in CLL.- Chapter 11. Role of Par-4 in inhibition of TCL1 induced growth.- Chapter 12. Par-4/THAP in survival of T-cell acute lympoblastic leukemia cells.- Chapter 13. Par-4 expression in cholangiocarcinoma.- Chapter 14. Par-4 suppresses breast cancer growth and invasion of breast cancer cells.- Chapter 15. PAWR as direct SRC-1/HOXC11 suppression target.- Chapter 16. Par-4 cleavage is required for TNF induced apoptosis.- Chapter 17. Par-4 secretagogues.- Chapter 18. Recombinant production and characterization of SAC.- Chapter 19. Anti-tumor effects of plant derived Par-4.- Chapter 20. Par-4 in Mycobacterium tuberculosis Infected Macrophages.- Part 2 - Role in other Diseases.- Chapter 21. Role of Par-4 in ceramide inducible effects in neurons.- Chapter 22. Role of Par-4 in Alzheimers disease.- Chapter 23. Dopamine signaling in association with induction of Par-4 protein expression.- Chapter 24. Par-4 (PAWR) in major depressive disorder.- Chapter 25. Par-4 dependent apoptosis of islet β cells in type 2 diabetes.- Chapter 26. Par-4 in cardiac fibroblast senescence.- Chapter 27. Par-4 in ocular development and disease.- Chapter 28. Par-4 in apoptosis during human salivary gland development.- Chapter 29. Suppression of Par-4 protects human renal proximal tubule cells from apoptosis.- Chapter 30. Lessons from knockout mice.- Part 3 - From Bench to Bedside.- Chapter 31. Par-4 secretagogues in clinical trials.- Chapter 32. Potential of Par-4 as a therapeutic target for cancer.
