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Full Description
This book addresses multiple aspects of biological clocks in prokaryotes.
The first part of the book deals with the circadian clock system in cyanobacteria, i.e. the pioneer of bacterial clocks. Starting with the history and background of cyanobacteria and circadian rhythms in microorganisms, the topics range from the molecular basis, structure and evolution of the circadian clock to modelling approaches, Kai systems in cyanobacteria and biotechnological applications.
In the second part, emergent timekeeping properties of bacteria in microbiomes and bacteria other than cyanobacteria are discussed.
Since the discovery of circadian rhythms in cyanobacteria in the late 1980s, the field has exploded with new information. The cyanobacterial model system for studying circadian rhythms (Synechococcus elongatus), has allowed a detailed genetic dissection of the bacterial clock due to state-of-the-art methods in molecular, structural, and evolutionary biology. Cutting-edge research spanning from cyanobacteria and circadian phenomena in other kinds of bacteria, to microbiomes has now given the field another major boost.
This book is aimed at junior and senior researchers alike. Students or researchers new to the field of biological clocks in prokaryotes will get a comprehensive overview, while more experienced researchers will get an update on the latest developments.
Contents
Chapter 1. Introduction.- Chapter 2. Around the Circadian Clock: Review and Preview.- Chapter 3. A retrospective: on disproving the transcription-translation feedback loop model in cyanobacteria.- Chapter 4. Mechanistic Aspects of the Cyanobacterial Circadian Clock.- Chapter 5. Mechanism of the cyanobacterial circadian clock protein KaiC to measure 24 hours.- Chapter 6. Oscillation and Input Compensation in the Cyanobacterial Kai Proteins.- Chapter 7. Insights into the Evolution of Circadian Clocks Gleaned from Bacteria.- Chapter 8. Reasons for Seeking Information on the Molecular Structure and Dynamics of Circadian Clock Components in Cyanobacteria.- Chapter 9. Single-molecule methods applied to circadian proteins with special on atomic force microscopy.- Chapter 10. Diversity of timing systems in Cyanobacteria and beyond.- Chapter 11. An In Vitro Approach to Elucidating Clock-modulating Metabolites.- Chapter 12. Damped Oscillation in the Cyanobacterial Clock System.- Chapter 13. Roles of phosphorylation of KaiC in the cyanobacterial circadian clock.- Chapter 14. Reprogramming metabolic networks and manipulating circadian clocks for biotechnological applications.- Chapter 15. Insights from Mathematical Modeling/Simulations of the in vitro KaiABC clock.- Chapter 16. Basic Biology of Rhythms & the Microbiome.- Chapter 17. Disease Implications of the Circadian Clocks and Microbiota Interface.- Chapter 18. Circadian organization of the gut commensal bacterium Klebsiella aerogenes.- Chapter 19. Daily rhythmicity in coastal microbial mats.- Chapter 20. Daily and Seasonal Rhythms of Marine Phages of Cyanobacteria.
