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Full Description
This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed.
Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as "collagenopathies" that affect a multitude of organs and tissues including sensorial organs.
The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.
Contents
Chapter 1: Introduction to the collagen superfamily.- Chapter 2: Collagen IV-related disease.- Chapter 3: Articular collagens related diseases.- Chapter 4: Collagens as new players of nervous system disease.- Chapter 5: Collagens and EDS.- Chapter 6: Collagens and dystrophic epidermolysis bullosa.- Chapter 7: Collagen-related myopathies: pathogenic mechanisms and prospective therapies.- Chapter 8: Procollagen trafficking and its implicaitons in Osteogenesis Imperfecta.
