Full Description
This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology.
In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung's innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease.
To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.
Contents
Sex Differences in Respiratory Physiology.- Sex Differences in the Anatomy of the Airways and the Lungs: Impact on Dysanapsis across the Lifespan.- Sex Steroids and Their Influence in Lung Diseases Across the Lifespan.- Sex Differences in the Developing Lung: Implications for Disease.- Neonatal Lung Disease: Mechanisms Driving Sex Differences.- Sex Differences in Cystic Fibrosis Across the Lifespan.- Sex Differences in Chronic Obstructive Pulmonary Disease.- Sex-Differences in Pulmonary Arterial Hypertension.- Sex and Gender Differences in the Susceptibility to Environmental Exposures.- Respiratory Sex Differences in Response to Smoke Exposure.- Sex Differences in Adaptive Immunity in Chronic Lung Disease.- Network Medicine and Systems Biology Considerations to Understand Sex Differences in Lung Disease.- Sex Differences in Respiratory Infection.- Androgen Excess in Women and the Respiratory System.- Sex Differences in Circadian Biology: Influences on Lung Health and Disease.- Sex Differences in the Coronavirus Disease 2019.
