Full Description
This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases.
The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
Contents
1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells.- 2. Na+-K+-2Cl- Cotransporter.- 3. Thiazide-sensitive NaCl Cotransporter.- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia.- 5. Na+/H+ Exchangers in Epithelia.- 6. Sugar Transport Across Epithelia.- 7. Amino Acid Transporters of Epithelia.- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX).- 9. Urea Transporters in Health and Disease.- 10. H,K-ATPases in Epithelia.- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells.- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters.- 13. ClC-2 Chloride Channels.- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology.- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine.- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator.- 17. TMEM16 Proteins (Anoctamins) in Epithelia.- 18. Epithelial Sodium Channels (ENaC).- 19. ROMK and Bartter Syndrome Type 2.- 20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron.- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels.- 22. KCa3.1 in Epithelia.- 23. BK Channels in Epithelia.- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels.- 25. KCNE regulation of KCNQ channels.- 26. Orai Channels.- 27. Trp Channels in Renal Epithelia.- 28. P2X receptors in Epithelia.- 29. The Polycystins and Polycystic Kidney Disease.- 30. Renal Aquaporins in Health and Disease.
