Full Description
This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies.
With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.
Contents
Synthesis of mimicks.- Melanin.- Rodlets and cell wall surface proteins.- Alpha 1,3 and Beta 1,3 glucans and remodelling.- Chitin.- Cell wall PAMPs and PRRs in mammalians.- Extracellular polysaccharides and biofilms.- Cell wall drugs and resistance mechanisms.- GPI proteins and cell wall.- Cell wall and morphogenesis.- Carbohydrate active enzymes in fungi B.- Glucanases and chitinases.- Respiration and cell wall synthesis.- Cell wall and environment.
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