Full Description
Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably "primitive") cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the "natural" immunity brought about by immune phagocytes.
The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.
Contents
An introduction to phagocytosis.- A Brief History of Phagocytosis.- The role of membrane surface charge in phagocytosis.- Receptor models of phagocytosis: the effect of target shape.- Decision Making in Phagocytosis.- Membrane tension and the role of ezrin during phagocytosis.- Molecular mechanisms of calcium signaling during phagocytosis.- Calpain activation by Ca2+ and its role in phagocytosis.- The NADPH oxidase and the phagosome.- Conclusions and the future of phagocytosis.-
