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Full Description
Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.
Contents
List of figuresList of abbreviationsAbout the authorsIntroduction1: Brief introduction on brain tumor epidemiology and state of the art in therapeuticsAbstract2: Blood-brain barrier pathophysiology in brain tumorsAbstract3: Brain drug-delivery attemptsAbstract4: Nanoparticles potential: types, mechanisms of action, actual in vitro and animal studies, recent patentsAbstract4.1 Nanomedicine and nanoparticles: general overview4.2 Main types of nanoparticles for drug-delivery systems4.3 Application in brain tumors4.4 Recent patents in brain tumors4.5 Nanotechnology5: Future scenarios: nanoparticles and stem cellsAbstract6: ConclusionsIndex
