Full Description
Recently, there has been renewed interest in the role played by bone in the development of osteoarthritis, including targeting bone as a potential therapeutic approach. The molecular and cellular approaches toward the relationship of joint and bone problems distinguish this from other books on osteoarthritis or skeletal medicine. Emphasis on genetics and newer viewpoints and approaches, gives a wider viewpoint and may make possible novel approaches to solving a clinical problem. The book will therefore also interest experienced specialists. Topics discussed include the role of bone in osteoarthritis, ranging from basic cell and molecular biology to genetics and biomechanics.
Intended for students, researchers and clinicians, the book provides information to enable the novice become oriented and the practitioner to update knowledge. This volume encompasses aspects of many specialties, including rheumatology, orthopedics, endocrinology, oncology, dentistry, geriatrics, nursing and chiropractic medicine.
Contents
The Pathogenesis of Osteoarthritis.- The Role of Bone in the Development of Osteoarthritis.- Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage.- The Synovium and Its Role in Osteoarthritis.- Cartilage Matrix Destruction.- Anabolic Mediators of Cartilage Healing.- Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface.- Genetic and Epigenetic Aspects of Osteoarthritis.- Animal Models.- Biomechanical Aspects: Joint Injury and Osteoarthritis.- Novel Osteoarthritis Therapeutics.
