Full Description
In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher incidence of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders such as Alzheimer's and Huntington's disease. By reproducing some of the pathological aspects of the diseases, these studies could reveal the mechanism for their onset or development. Some of the transgenic mice can also be used as targets for testing new compounds with the potential to prevent or combat these disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics. The chapters cover disorders including: Alzheimer's disease, Parkinson's disease, Huntington's and other CAG diseases, amyotrophic lateral sclerosis (ALS), recessive ataxias, disease caused by prions, and ischemia.
Contents
Preface;
Animal models on Alzheimer Disease;
Animal models for Amyloid/PS-1 Pathology;
Transgenic mice overexpressing GSK-3beta as animal models of Alzheimer Disease;
Reelin and Alzheimer Disease;
Tauopathy models;
Animal models for Parkinson Disease I;
Animal models for Parkinson Disease II;
Neuroprotection in Parkinson Disease;
Animal models for ALS;
Mouse models of Huntington's Disease;
Recesive Ataxias;
Mouse models in PrP-related diseases;
Mouse models of ischemia;
