Preclinical Drug Discovery : High Throughput Screening and Compound Progression Strategies (Rsc Drug Discovery) / Gul, Sheraz (EDT)/ Rotella, David (EDT)/ Thurston, David E. (EDT)/ Has

Preclinical Drug Discovery : High Throughput Screening and Compound Progression Strategies (Rsc Drug Discovery) 〈1〉

Gul, Sheraz (EDT)/ Rotella, David (EDT)/ Thurston, David E. (EDT)/ Has

Royal Society of Chemistry（2014/06発売）

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製本 Hardcover:ハードカバー版／ページ数 288 p.
言語 ENG
商品コード 9781849731348
DDC分類 572

Full Description

This book is one of a three-volume set that provides theoretical, practical and troubleshooting guidelines on all aspects of the pre-clinical Drug Discovery process. There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of "Hits" to "Leads" and "Candidates" The books will also fill current gaps in the literature such as primary, stem cell and other novel assay methods. Other relatively new research areas included are siRNA, high content screening, protein-protein interactions, pathway assays, non micro-titre plate based assays, label free assays, IT tools, approaches to identify biopharmaceuticals, emerging models and future trends in Drug Discovery.

Volume 1Fluorescence intensity; Fluorescence polarisation; FRET, TR-FRET/HTRF; AlphaScreen; Fluorescence lifetime; Scintillation Proximity Assay; Chip based assays; Label free assays; Calorimetry; ELISA; Volume 2: Cell Based Methods in High Throughput Screening: Fluorescence intensity; FRET, TR-FRET/HTRF; AlphaScreen; Reporter gene assays; Luminescence & Bioluminescence; Scintillation Proximity Assay; Calcium mobilization (FLIPR); cAMP assays; Electrophysiology; Cellular imaging & fluorescent microscopy; Label free assays; Volume 3: Pre-Clinical Drug Discovery, High Throughput Screening and Compound Progression Strategies: The Drug Discovery process; Target classes and validation; Assays in Drug Discovery: biochemical vs cellular; Enzyme kinetics; Receptor kinetics in drug screening programmes; Biological reagents for High Throughput Screening; Automation vs manual operation of screening tasks; Analysis of High Throughput Screening data; Compound Mechanism of Action studies; Counter, Selectivity, Viability and Liability assays; Screening for undesirable compounds; Toxicology profiling; Compound characterization: physico-chemical properties; Index