基本説明
Visual guide to differential diagnosis and new therapies for IBD.
Full Description
Inflammatory bowel disease (IBD) is a chronic condition in which the lining of the digestive tract becomes inflamed and covered with ulcers. There are two types of IBD: ulcerative colitis, which causes inflammation and ulcers in the lining of the rectum and colon; and Crohn's disease which causes inflammation deeper within the intestinal wall of the small intestine and can occur in other parts of the digestive system including the mouth, oesophagus, and stomach. Although both conditions are characterized by inflammation and ulceration, they are in fact different disease processes and their treatments can differ. However, the goal of IBD treatment is to eliminate inflammation and there are many types of anti-inflammatory drugs currently available. In this beautifully illustrated new book, a specialist team of three physicians and one surgeon address some of the major questions surrounding this interesting group of diseases. Key topics include: new investigative techniques; differential diagnosis and management of specific disease states; complex manifestations of IBC and in-depth presentation of new therapeutic modalities.
This book will provide an invaluable visual reference for doctors and surgeons interested in gastrointestinal disease, general physicians and for doctors and surgeons in training.
Contents
Contributors Abbreviations PART I: DIAGNOSIS AND MANAGEMENT OF INFLAMMATORY BOWEL DISEASE 1. Introduction: aetiology and clinical presentation * Differences between Crohn's disease and ulcerative colitis * Aetiology * Genetic factors * Environmental factors * Recommended reading * Clinical presentation * Introduction * Luminal symptoms of CD * Luminal symptoms of UC * Extraintestinal manifestations * Symptoms related to complications * Recommended reading 2. Investigations at diagnosis * Introduction * Laboratory investigations * Endoscopy * Sigmoidoscopy * Ileocolonoscopy * Appearances at endoscopy * Upper GI endoscopy (oesophago-gastro-duodenoscopy (OGD)) * Capsule endoscopy * Radiology * CT scanning * White cell scanning * Ultrasound * Magnetic resonance imaging (MRI) * Histopathology * Recommended reading 3 Pathology of inflammatory bowel disease * Introduction * Pathology of CD * Pathology of UC * Malignancy in IBD * Pathological changes seen after surgery for IBD 4 Management of inflammatory bowel disease * Principles of management and general observations * Maintenance of remission * Management of left-sided UC * Treatment of active left-sided UC * Treatment of left-sided UC refractory to 5-ASAs and rectal corticosteroids * Refractory left-sided UC * Steroid-dependent disease * Recommended reading * Management of extensive UC * Initial management * Other immune suppressants * Surgery * Acute severe or persistent active disease * Recommended reading * Management of CD * Introduction * Treatment of active disease * Treatment of relapsing or refractory disease * Other drugs and treatments for active CD * Maintaining remission in CD * Prevention of post-operative recurrence * New therapeutic approaches * Stopping treatment in CD PART II: COMPLICATIONS AND COMORBIDITIES 5. Acute, severe colitis * Introduction * Diagnosis * Investigations * Clinical parameters * Laboratory parameters * Radiological and endoscopic parameters * Treatment * Nutritional support * Antibiotic therapy * Second-line or 'rescue' therapy * Third-line therapy * Recommended reading 6. Perianal and fistulizing Crohn's disease * Perianal disease * Fistulizing CD: special situations * Recommended reading 7. Microscopic colitis * Introduction * Recommended reading 8. Fertility and inflammatory bowel disease * Introduction * Pregnancy and IBD * Pregnancy and restorative proctocolectomy * Medications during pregnancy * Recommended reading 9. Extraintestinal manifestations * Introduction * Arthritis * Skin manifestations * Ocular manifestations * Liver disease * Recommended reading 10. Malignancy in inflammatory bowel disease * Colon cancer 87 * Interventions to minimize risk * Other malignancies in IBD * Drugs PART III: OVERVIEW OF THERAPEUTIC MODALITIES IN INFLAMMATORY BOWEL DISEASE 11. Drugs for inflammatory bowel disease * Introduction * Anti-inflammatory agents * Immune suppressants (immunomodulators) * Biological therapies 12. Surgery in inflammatory bowel disease * Introduction * Ulcerative colitis * Surgery for CD * Recommended reading Index
