Full Description
The most comprehensive text of its kind, this book addresses both the management of opioid withdrawal and opioid maintenance therapy, and combines up-to-date reviews of the scientific literature with evidence-based clinical guidelines for all of the relevant pharmacotherapies.
A unique work, Pharmacotherapies for the Treatment of Opioid Dependence presents:
· detailed information on the cost-effectiveness of the various types of opioid treatment
· the range of pharmacotherapies used for the management of opioid dependence
· the state of knowledge from the international research literature on the value and relative efficacy of the various pharmacological approaches.
This includes pharmacotherapies used in the management of withdrawal from opioids such as clonidine, lofexidine, methadone, buprenorphine and naltrexone and also symptomatic medications. It also includes different forms of maintenance therapy using opioid agonists such as methadone, LAAM, buprenorphine, slow-release oral morphine and diamorphine, and opioid antagonists such as naltrexone.
This text should appeal to researchers, to identify gaps in the research literature and provide a basis for determining appropriate research directions, to clinicians by providing clinical with clinical guidelines and information concerning the empirical basis for the treatments, and to policy makers in assisting them to make decisions about the various treatments from a public health perspective, taking into account the relative cost and effectiveness of the interventions.
Contents
Part I: Introduction 1. Opioid dependence and management 2. Pharmacology of opioid agonists and antagonists Part II: Outcomes for Withdrawal 3. Services for heroin withdrawal: A review Part III: Outcomes for Maintenance Treatment 4. Methadone maintenance treatment 5. LAAM in the treatment of opioid dependence: A systematic review 6. The place of buprenorphine in the management of opioid dependence 7. Treating heroin dependence with diamorphine (pharmaceutical heroin) 8. Naltrexone maintenance treatment Part IV: Outcomes from the National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD) Project 9. Pharmacotherapies and pregnancy 10. Politics, practice, and research into treatment of heroin addiction 11. Clinical guidelines and procedures for the use of methadone in the maintenance treatment of opioid dependence 12. National clinical guidelines and procedures for the use of buprenorphine in the treatment of heroin dependence 13. Clinical guidelines and procedures for the use of naltrexone in the management of opioid dependence 14. Choosing treatments: The role of economics in informing future decisions
