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Full Description
Bisphenol A (BPA) is a high production volume endocrine-disrupting chemical present in numerous consumer products. Extensive use of BPA has led to wide-spread contamination in the air, soil, and water, leading to ubiquitous human exposure. Research into BPA has grown exponentially over the past ten years, with numerous modes of action being identified that impact human health and disease development. While BPA has estrogenic effects, emerging literature has identified several non-receptor mediated modes of action, such as epigenetic reprogramming, that can affect the long-term health of the population. This book highlights the multiple modes of action BPA can use to reprogram cells genetically and metabolically. By compiling critical studies in BPA and outlining the connections and disparities in the literature to build a broader understanding of this complex endocrine-disrupting chemical and its impact on the environment and human health, this book is an ideal resource for postgraduates and researchers in a range of disciplines from toxicology to epigenetics and cancer epidemiology.
Contents
Classical and Non-classical Estrogen Receptor Efects of Bisphenol A;
Genotoxicity and Mutagenicity of Bisphenol A;
Bisphenol A (BPA) Associated Signaling Pathways in Human Diseases;
Bisphenol A and its Impact on Human Telomerase, Telomere Length and Cell Aging;
The Role of Bisphenol A in Development of Autoimmunity;
A Novel Model for the Estrogenic Action of BPA in Developing Brain Following Maternal Ingestion;
Bisphenol A's Pleiotropic Effects Alter Milk Synthesis and Production
