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Full Description
Toxoplasma gondii is a globally spread protozoan parasite responsible for causing toxoplasmosis. Infection by T. gondii shows high seroprevalence in humans, especially in South America. Written by specialists, this book brings important contributions and information on parasite biology, including its life cycle, ultrastructural features of tachyzoite, bradyzoite and their main specific organelles, mechanisms of host cell invasion, parasite replication and epigenetics regulation. Moreover, the book will encompass mechanisms of pathogenesis and host immune response to the infection, including purinergic signalling, and mechanisms of immune evasion by the parasite. Finally, this book also addresses relevant aspects of disease, information about the current chemotherapy of toxoplasmosis and perspectives for a future chronic disease treatment, epidemiology, and methods for visualisation of the parasite by optical and electron microscopy.
Contents
Preface; Toxoplasma gondii: Introduction to Parasite Life Cycle and Disease; Ultrastructure of Tachyzoite, Sporozoite and Bradyzoite Forms; Toxoplasma Gondii Entry Mechanisms and Establishment of the Parasitophorous Vacuole; Cystogenesis Process in Toxoplasma Gondii; Toxoplasma Gondii Cell Division: Back To The Source; Epigenetic Regulation Affects Essential Mechanisms in Toxoplasma Gondii; The Balance Between Host Cell-Autonomous Immunity and Toxoplasma Gondii Evasion Strategies; Purinergic Signaling in the Host Resistance to Toxoplasma Gondii Infection; Metastatic-Like Phenotype of Monocytes/Macrophages Induced by Toxoplasma Gondii Infection: MMPS, UPA/UPAR and CD147 Involvement at Early Infection and Dissemination; Over the Top: Arm Wrestling Between Toxoplasma Gondii and Host Skeletal Muscle Tissue; Current Treatment of Toxoplasmosis; Advances in the Development of Treatments for the Chronic Phase of Toxoplasmosis; Prevalence of Toxoplasma Gondii Infection in South America; Cerebral Toxoplasmosis in People Living with HIV/AIDS; Toxoplasma Gondii: Ocular Disease; Imaging Techniques in the Study of Toxoplasma Gondii; Index.
