Full Description
Leading academic and biomedical researchers comprehensively review the status of essential fatty acids (EFA) in nutrition, medicine, psychology, and pharmacology. Topics range from a discussion of EFA basic mechanisms to their effects on individual psychiatry and behavior, and include extensive coverage of pathology, DHA in CNS development, and phospholipid and fatty acid composition and metabolism. Comprehensive and forward-looking, Fatty Acids: Physiological and Behavioral Functions reviews and critically evaluates our current knowledge of EFA, setting the stage for oncoming wave of discovery about the biochemical and molecular functions of essential fatty acids, as well as their critical role in human physiology, immunology, and behavior.
Contents
Part I. Basic Mechanisms
Evolutionary Aspects of Diet: Essential Fatty Acids
Artemis P. Simopoulos
Modulation of Receptor Signaling by Phospholipid Acyl Chain Composition
Drake C. Mitchell and Burton J. Litman
Role of Docosahexaenoic Acid in Determining Membrane Structure and Function: Lessons Learned from Normal and Neoplastic Leukocytes
Laura J. Jenski and William Stillwell
Effects of Essential Fatty Acids on Voltage-Regulated Ionic Channels and Seizure Thresholds in Animals
Robert A. Voskuyl and Martin Vreugdenhil
Role of Dietary Fats and Exercise in Immune Functions and Aging
Jaya T. Venkatraman and David Pendergast
Part II. Phospholipid and Fatty Acid Composition and Metabolism
On the Relative Efficacy of _-Linolenic Acid and Preformed Docosahexaenoic Acid as Substrates for Tissue Docosahexaenoate During Perinatal Development
Meng-Chuan Huang and J. Thomas Brenna
Recent Advances in the Supply of Docosahexaenoic Acid to the Nervous System
Robert J. Pawlosky and Norman Salem Jr
Quantifying and Imaging Brain Phospholipid Metabolism In Vivo Using Radiolabeled Long Chain Fatty Acids
Stanley I. Rapoport
Carbon Recycling: An Important Pathway in _-Linolenate Metabolism in Fetuses and Neonates
Stephen C. Cunnane
Part III. DHA and CNS Development
Impact of Dietary Essential Fatty Acids on Neuronal Structure and Function
M. Thomas Clandinin, R.A.R. Bowen, and Miyoung Suh
Dietary N-3 Fatty Acid Deficiency and its Reversibility: Effects upon Brain Phospholipids and the Turnover of Docosahexaenoic Acid in the Brain and Blood
William E. Connor, Gregory J. Anderson, and Don S. Lin
The Role of Omega-3 Polyunsaturated Fatty Acids in Retinal Function
Algis J. Vingrys, James A. Armitage, Harrison S. Weisinger, B.V. Bui, Andrew J.Sinclair, and Richard S. Weisinger
Brightness-Discrimination Learning Behavior and Retinal Function Affected by Long-Term _-Linolenic Acid Deficiency in Rat, Harumi Okuyama
Yoichi Fujii, and Atsushi Ikemoto
Part IV. Pathology
Disturbances of Essential Fatty Acid Metabolism in Neural Complications of Diabetes
Joseph Eichberg and Cristinel Mîinea
Docosahexaenoic Acid Therapy for Disorders of Peroxisome Biogenesis
Hugo W. Moser and Gerald V. Raymond
Effects of Fatty Acids and Ketones on Neuronal Excitability: Implications for Epilepsy and its Treatment
Carl E. Stafstrom
Fatty Acid Ethyl Esters: Toxic Nonoxidative Metabolites of Ethanol
Zbigniew M. Szczepiorkowski and Michael Laposata
Part V. Psychiatry and Behavior
Omega-3 Fatty Acids and Psychiatric Disorders: Current Status of the Field
Joseph R. Hibbeln and Norman Salem Jr
Disorders of Phospholipid Metabolism in Schizophrenia, Affective Disorders, and Neurodegenerative Disorders
David F. Horrobin
Eicosapentaenoic Acid: A Potential New Treatment for Schizophrenia?
Malcolm Peet and Shaun Ryles
The Importance of DHA in Optimal Cognitive Function in Rodents
Claus C. Becker and David J. Kyle
The Role of Omega-3 Polyunsaturated Fatty Acids in Body Fluid and Energy Homeostasis
Richard S. Weisinger, James A. Armitage, Peta Burns, Andrew J. Sinclair, Algis J. Vingrys, and Harrison S. Weisinger
PUFA: Mediators for the Nervous, Endocrine, and Immune Systems
Shlomo Yehuda, Sharon Rabinovitz, and David I. Mostofsky
