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Full Description
This book focuses on the structural, biochemical, and diverse functional properties of the endothelial luminal membrane glycocalyx (ELMG), an organelle which constitutes the endothelial cell "membrane." It is intended to provide the newcomer with a broad, basic, and brief perspective of the luminal endothelial vascular membrane, and for the more established investigator, a basic overview and integrated perspective of the "universe" we explore.
The endothelium is an assortment of heterogeneous regulatory cells whose cytoplasm and cell membranes are joined, forming functional units. There is a tremendous amount of literature on the endothelial cell, constituting seemingly isolated and distinct fields of encapsulated research. However, the multifunctional properties of some molecules give rise to an overlap of findings, frequently ignored between the different fields.
The book is divided into three parts. The first part concentrates on the structure of the ELMG, with emphasis on morphological and biochemical composition. The importance of the chemical composition to the physiological functions of the ELMG, such as sieving properties, pharmacology, and flow sensing, is the focus of the second part of the book. Finally, some of the pathologies associated with ELMG dysfunction are explored in the last section.
The aim is to provide basic and well-established knowledge in the various individual fields, identify the current concepts in each area, and discuss their respective strengths and weaknesses (including hidden problems). Finally, the overall goal is to integrate areas where overlap is clearly indicated, bringing them all together to provide the first ever basic, integrative, panoramic bird's-eye view of the field.
Contents
Preface
Acknowledgments
PART I THE DISTINCT MORPHOLOGICAL, PHYSICAL, BIOCHEMICAL, AND STRUCTURAL PROPERTIES OF T HE ENDOTHELIAL LUMINAL MEMBRANE-GLYCOCALYX (ELMG)
1. The Endothelial Cell in situ is not an Isolated Cell, but a Complex of Cells
2. Morphological Structures: Diversity, Heterogeneity, and Appearance Depends on Staining Procedure
3. ELMG Structures Responsible for Interacting Forces
4. The Diverse Biochemical Composition of the ELMG
PART II THE DIVERSE STRUCTURAL PROPERTIES OF THE ENDOT HELIAL LUMINAL MEMBRANE-GLYCOCALYX (ELMG) DETERMINE ITS PHYSIOLOGICAL RESPONSES
5. Sieving Properties of the ELMG Are Selective and Dynamic and in Series with Active Membrane Transport Systems
6. Pharmacological and Compartmentalizing Properties of the ELMG
7. Flow Sensing Properties of the ELMG
PART III PATHOLOGICALLY-INDUCED ALTERATIONS OF ENDOTHELIAL LUMINAL MEMBRANE GLYCOCALYX (ELMG)
8. The ELMG in Pathophysiological Conditions
Author Biographies
