Full Description
The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.
Contents
Part Ifunction with PET/CT2: PET/MRI3: SPECT and SPECT/CT4: Principles of micro x-ray computed tomography5: Small Animal SPECT, SPECT/CT, and SPECT/MRI6: Instrumentation and methods to combine small animal PET with other imaging modalities7: Functional Imaging using Bioluminescent Imaging8: Optical Multimodality9: Fiber Optic Fluorescence Imaging10: Fluorescence Tomography11: Endomicroscopy12: Intravital Microscopy13: Diffuse Optical Tomography14: Ultrasound15: Molecular Photoacoustic Tomography16: Optical Projection Tomography17: Signal Post Processing/Image ReconstructionPart II: Chemistry of Molecular Imaging18: Chemistry of Molecular Imaging: an overview19: Radiochemistry of PET20: Radiochemistry of SPECT21: Nanochemistry for Molecular Imaging22: Newer Bioconjugation Methods23: Targeted Antibodies and Peptides24: Hyperpolarized 13C magnetic resonance imaging - Principles and applications25: MR Imaging Agents26: Optical Imaging Agents27: Ultrasound Contrast Agents28: Multimodality Agents29: "Click Chemistry": Applications to Molecular Imaging30: The "One-Bead-One-Compound" Combinatorial Approach toIdentifying Molecular Imaging Probes31: Chemical Biology Approaches to Molecular Imaging32: Theranostics: Agents for diagnosis and therapy33: Magnetic Nanoparticles34: Fluorocarbon Agents For Quantitative Multimodal Molecular Imaging and Targeted Therapeutics35: Aptamers for Molecular Imaging36: ToxicologyPart III: Molecular Imaging in Cell & Molecular Biology37: Overview of Molecular and Cell Biology38: Systems Biology39: Protein Engineering40: Phage Display for Agent Development41: Molecular Imaging of Gene Therapy42: Developing diagnostic and therapeutic viral vectors43: Cell Voyeurism using Magnetic Resonance Imaging44: Tumor vasculature45: Hypoxia Imaging46: Protein-Protein Interaction47: Fluorescence Reporters/Activatable Cell Penetrating Peptides48: Imaging of Signaling PathwaysPart IV: Applications of Molecular Imaging49: Molecular and Functional Imaging of the Tumor Microenvironment50: Novel MR and PET Imaging in the RT Planning and Assessment of Response of Malignant Gliomas 51: PET Diagnosis and Response Monitoring in Oncology52: MRS Treatment Response and Detection53: MRI Treatment Response Assessment - Diffusion54: Myocardial Metabolism55: Congestive Heart Failure56: Molecular Imaging of Atherosclerosis57: Thrombosis and Embolism58: Molecular Imaging of Stem Cells in Myocardial Infarction59: Central Nervous System Molecular Imaging60: Neuroreceptor Imaging61: Neurodegeneration62: Molecular Imaging of Autoimmune Diseases63: Rheumatoid Arthritis64: Autoimmune Diabetes65: Imaging in AsthmaPart V: Molecular Imaging in Drug Evaluation66: Molecular and Functional Imaging in Drug Development67: PET Imaging Clinical Trials68: MR Imaging in Clinical Trials69: Imaging of Gene Therapy: Basis and Clinical TrialsPart VI: Other70: Visualization71: Quantification of Radiotracer Uptake into Tissue72: Mining High Throughput Data for Candidate Biomarkers as Imaging and Therapeutic Targets73: Pharmacokinetic Modeling74: Cost-Effectiveness Analysis/Economics of Probe Development75: Regulatory and Reimbursement Process for Imaging Agents and Devices
