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基本説明
Provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration.
Full Description
This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly - chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.
Contents
I. Molecules and Pathways of Apoptosis.- Caspases: Activation, Regulation, and Function.- The Bcl-2 Family Proteins.- The Mammalian IAPs: Multifaceted Inhibitors of Apoptosis.- Structural Biology of Programmed Cell Death.- The Death Receptor Pathway.- The Mitochondrial Pathway: Focus on Shape Changes.- The Endoplasmic Reticulum Pathway.- Reactive Oxygen Species in Cell Fate Decisions.- The Integration of Metabolism and Cell Death.- Transcriptional Regulation of Apoptosis.- Clearance of Apoptotic Cells - Mechanisms and Consequences.- Systems Biology Approaches to the Study of Apoptosis.- II: Apoptosis in Model Organisms.- Programmed Cell Death in Plants: Apoptotic but Not Quite.- Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae.- Programmed Cell Death in C. elegans.- Cell Death in Drosophila.- III. Apoptosis in Mammalian Physiology and Pathogenesis.- Cell Death: Defining and Misshaping Mammalian Embryos.- Matters of Life and Death in the Immune System.- Cell Death in the Hematopoietic System.- Cell Death in Acute Neuronal Injury.- Apoptosis in Neurodegenerative Diseases.- Apoptosis in Cardiovascular Pathogenesis.- Apoptosis in Lung Injury and Disease.- Apoptosis in Liver Injury and Liver Diseases.- Apoptosis in Acute Kidney Injury.- Apoptosis in Cancer Biology and Cancer Therapeutics.- IV. Alternative cell death mechanisms and pathways.- Necrosis: Molecular Mechanisms and Physiological Roles.- Caspase-Independent Mitotic Death.- Lysosomal Proteases in Cell Death.- Autophagy and Cell Death.- V. Approaches to the study of apoptosis.- Analysis of Apoptosis: Basic Principles and Protocols.
