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Full Description
Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein export from bacteria, vesicular transport that delivers to its final destination most of what has been transported into the ER, and protein export from the ER that is associated with protein degradation (termed ERAD). Over the years, protein transport into the ER also has become part of the quest to understand the various roles of molecular chaperones under non-stress conditions and of the ribosomal tunnel exit as the decisive site for molecular triage of nascent polypeptide chains.
Contents
Preface 1. Post-Targeting Function s of Signal Peptides 2 . mRNA Translation on the Endoplasmic Reticulum: Kinetic Advantages to Protein Synthesis on the E R .3. Translocon Organization in Cells 4 . Structure of the Sec61 - Complex 5. Sec C o m p lex es in the Yeast ER 6. The Role of BiP and Its Co -Chaperones 7 Membrane Protein Biosynthesis at the Endoplasmic Reticulum 8 . Membrane Insertion of Tail-Anchored Proteins. 9. Human Pathologies of Protein Transport into the Endoplasmic Reticulum
