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基本説明
Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis.
Full Description
The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment.Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis.Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen interactions, antifungal resistance and drug discovery, and diagnostics to foster better understanding and treatment of candidiasis.Examines recent discoveries that have shed light on morphogenesis and the cell cycle, including how new findings on host responses may have applications for the diagnosis of blood-borne candidiasis.This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of ContentsContributorsPreface1 Candida: What Should Clinicians and Scientists Be Talking About? Brad Spellberg, Kieren A. Marr, and Scott G. FillerSECTION I: The Organisms, Their Genomics, and Variability2 An Introduction to the Medically Important Candida SpeciesGary Moran, David Coleman, and Derek Sullivan3 Comparative Genomics of Candida SpeciesGeraldine Butler4 The Genetic Code of the Candida CTG CladeAna Catarina Gomes, Gabriela R. Moura, and Manuel A. S. Santos5 Genome Instability and DNA RepairGerman Larriba and Richard A. Calderone6 Switching and MatingDavid R. Soll7 Detection and Clinical Significance of Variability among Candida IsolatesLois L. Hoyer8 Cell Cycle and Growth Control in Candida SpeciesCheryl A. Gale and Judith BermanSECTION II: Host-Pathogen Interactions (The Host)9 Immunology of Invasive CandidiasisLuigina Romani10 Mucosal Immunity to Candida albicansPaul L. Fidel, Jr., and Mairi C. Noverr11 Innate Immunity to Candida InfectionsMihai G. Netea and Neil A. R. Gow12 Vaccines and Passive Immunity against Candidiasisrad Spellberg, Yue Fu, and Ashraf S. Ibrahim13 Salivary Histatins: Structure, Function, and Mechanisms of Antifungal ActivityWoon Sik Jang and Mira EdgertonSECTION III: Host-Pathogen Interactions (The Pathogen)14 The Cell Wall: Glycoproteins, Remodeling, and RegulationCarol Munro and Mathias L. Richard15 Stress Responses in CandidaAlistair J. P. Brown, Ken Haynes, Neil A. R. Gow, and Janet Quinn16 Adhesins in Opportunistic Fungal PathogensRebecca Zordan and Brendan Cormack17 Encounters with Mammalian Cells: Survival Strategies of Candida SpeciesSlavena Vylkova and Michael C. Lorenz18 Gene Expression during the Distinct Stages of CandidiasisDuncan Wilson, Francois Mayer, and Bernhard Hube19 Biofilm Formation in Candida albicansJonathan Sewell Finkel and Aaron P. Mitchell20 Candida spp. in Microbial Populations and Communities: Molecular Interactions and Biological ImportanceAmy E. Piispanen and Deborah A. Hogan21 Back to the Future: Candida Mitochondria and EnergeticsDeepu Alex, Richard Calderone, and Dongmei LeeSECTION IV: Antifungal Drugs, Drug Resistance, and Discovery22 Antifungals: Drug Class, Mechanisms of Action, Pharmacokinetics/Pharmacodynamics, Drug-Drug Interactions, Toxicity, and Clinical UseJeniel E. Nett and David R. Andes23 The Impact of Antifungal Drug Resistance in the ClinicRussell E. Lewis and Dimitrios P. Kontoyiannis24 Insights in Antifungal Drug DiscoveryFrancoise Gay-Andrieu, Jared May, Dongmei Li, Nuo Sun, Hui Chen, Richard Calderone, and Deepu Alex25 Multidrug Resistance Transcriptional Regulatory Networks in CandidaP. David Rogers and Katherine S. BarkerSECTION V: Candidiasis, Evolving Diagnostics, and Treatment Paradigms26 Mucosal CandidiasisSanjay Revankar and Jack D. Sobel27 Systemic Candidiasis: Candidemia and Deep-Organ InfectionsCornelius J. Clancy and M. Hong Nguyen28 New Developments in Diagnostics and Management of Invasive CandidiasisSujatha Krishnan and Luis Ostrosky-Zeichner29 The Epidemiology of Invasive CandidiasisMichael A. Pfaller and Daniel J. DiekemaSECTION VI: Cool Tools for Research30 Cool Tools 1: Development and Application of a Candida albicans Two-Hybrid SystemBram Stynen, Patrick Van Dijck, and Helene Tournu31 Cool Tools 2: Development of a Candida albicans Cell Surface Protein MicroarrayA. Brian Mochon32 Cool Tools 3: Large-Scale Genetic Interaction Screening in Candida albicansYeissa Chabrier-Rosello, Anuj Kumar, and Damian Krysan33 Cool Tools 4: Imaging Candida Infections in the Live HostSoumya Mitra, Thomas H. Foster, and Melanie Wellington34 Cool Tools 5: The Candida albicans ORFeome ProjectMelanie Legrand, Carol Munro, and Christophe d'EnfertIndex
