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基本説明
Covers both the Cryptococcus neoformans and Cryptococcus gattii species, examining in detail the life cycle, pathophysiology, molecular biology, genetics, genomics, epidemiology, immunology, and clinical management of this encapsulated yeast.
Full Description
The full range of scientific and clinical perspectives on Cryptococcus at your fingertips.Covers both the Cryptococcus neoformans and Cryptococcus gattii species, examining in detail the life cycle, pathophysiology, molecular biology, genetics, genomics, epidemiology, immunology, and clinical management of this encapsulated yeast. Provides in-depth discussions of the 1999 Vancouver Island C. gattii outbreak that spread to the Canadian mainland and the United States, causing infections in both humans and animals. Discusses diagnosis, treatment, prevention, and other clinical perspectives on Cryptococcus infectionServes as a resource for molecular biologists, microbiologists, public health officials, epidemiologists, and infectious disease clinicians. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of ContentsI. GENERAL PRINCIPLES1. Systematics of the Genus Cryptococcus and Its Type Species C. neoformans, Kyung J. Kwon-Chung, Teun Boekhout, Brian L. Wickes, and Jack W. Fell2. The History of Cryptococcus and Cryptococcosis, John R. Perfect and Arturo Casadevall3. Biosynthesis and Genetics of the Cryptococcus Capsule, Guilhem Janbon and Tamara L. Doering4. The Architecture and Antigenic Composition of the Polysaccharide Capsule, Marcio L. Rodrigues, Arturo Casadevall, and Oscar Zaragoza5. Melanin: Structure, Function, and Biosynthesis in Cryptococcus, David Trofa, Arturo Casadevall, and Joshua D. Nosanchuk6. The Cell Wall of Cryptococcus, Nicole M. Gilbert, Jennifer K. Lodge, and Charles A. Specht7. Sexual Reproduction of Cryptococcus, Yen-Ping Hsueh, Xiaorong Lin, Kyung J. Kwon-Chung, and Joseph Heitman8. Population Structure and Ecology of Cryptococcus neoformans and C. gattii, Anastasia P. Litvintseva, Jianping Xu, and Thomas G. MitchellII. GENETICS AND GENOMICS9. The Cryptococcus Genomes: Tools for Comparative Genomics and Expression Analysis, James W. Kronstad, Brendan J. Loftus, and Jennifer K. Lodge10. Genetic and Genomic Approaches to Cryptococcus Environmental and Host Responses, Alexander Idnurm and Peter R. Williamson11. The Mating Type Locus of Cryptococcus: Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction, from the Phylogenomic Perspective, Yen-Ping Hsueh, Banu Metin, Keisha Findley, Marianela Rodriguez-Carres, and Joseph HeitmanIII. SIGNALING AND VIRULENCE12. G-Protein Signaling Pathways Regulating Morphogenesis and Virulence of Cryptococcus, J. Andrew Alspaugh, Connie B. Nichols, Chaoyang Xue, Wei-Chiang Shen, and Ping Wang13. A Role for Mating in Cryptococcal Virulence, Kirsten Nielsen and Kyung J. Kwon-Chung14. Sensing Extracellular Signals in Cryptococcus neoformans, Alexander Idnurm, Yong-Sun Bahn, Wei-Chiang Shen, Julian C. Rutherford, and Fritz A. Muhlschlegel15. Virulence Mechanisms of Cryptococcus gattii: Convergence and Divergence, Sudha Chaturvedi and Vishnu Chaturvedi16. Drug Resistance in Cryptococcus: Epidemiology and Molecular Mechanisms, Michael A. Pfaller, Jennifer K. Lodge, and M. A. Ghannoum17. Signaling Cascades and Enzymes as Cryptococcus Virulence Factors, Deborah S. Fox, Julianne Djordjevic, and Tania C. SorrellIV. ENVIRONMENTAL INTERACTIONS AND POPULATION GENETICS18. Environmental Niches for Cryptococcus, Thomas G. Mitchell, Elizabeth Castaneda, Kirsten Nielsen, Bodo Wanke, and Marcia S. Lazera19. Cryptococcus neoformans: Nonvertebrate Hosts and the Emergence of Virulence, Jeffrey J. Coleman, Cara J. Chrisman, Arturo Casadevall, and Eleftherios Mylonakis20. Cryptococcosis in Africa, Nelesh Govender, Thomas G. Mitchell, Anastasia P. Litvintseva, and Kathleen J. Miglia21. Cryptococcosis in Asia, Jiangping Xu, Weerawat Manosuthi, Uma Banerjee, Li-Ping Zhu, Janghan Chen, Shigeru Kohno, Koichi Izumikawa, Yuchong Chen, Somnuek Sungkanuparph, Thomas S. Harrison, and Matthew Fisher22. Sexual Reproduction of Cryptococcus gattii: a Population Genetics Perspective, Dee Carter, Leona Campbell, Nathan Saul, and Mark Krockenberger23. The Emergence of Cryptococcus gattii Infections on Vancouver Island and Expansion in the Pacific Northwest, Karen Bartlett, Edmond Byrnes, Colleen Duncan, Murray Fyfe, Eleni Galanis, Joseph Heitman, Linda Hoang, Sarah Kidd, Laura MacDougall, Sunny Mak, Kieren Marr, Muhammad Morshed, Sarah Klizas West, and James Kronstad24. Molecular Typing of the Cryptococcus neoformans/C. gattii Species Complex, Wieland Meyer, Felix Gilgado, Popchai Ngamskulrungroj, Luciana Trilles, Ferry Hagen, Elizabeth Castaneda, and Teun Boekhout25. Hybridization and Its Importance in the Cryptococcus Species Complex, Massimo Cogliati, Xiaorong Lin, and Maria Anna VivianiV. INTERACTIONS WITH THE IMMUNE SYSTEM26. The Interaction of Cryptococcus neoformans with Host Macrophages and Neutrophils, Travis McQuiston and Maurizio Del Poeta27. T-Cell and Dendritic-Cell Immune Responses to Cryptococcus, Karen L. Wozniak and Stuart M. Levitz28. Acquired Humoral Immunity to Cryptococcus neoformans, Liise-anne Pirofski and Arturo Casadevall29. Interactions of Capsule with Antibody and Complement, Thomas R. Kozel30. Cryptococcus Interactions with Innate Cytotoxic Lymphocytes, Shaunna M. Huston and Christopher H. Mody31. Cryptococcus neoformans: Latency and Disease, Francoise Dromer, Arturo Casadevall, John Perfect, and Tania Sorrell32. Intracellular Replication and Exit Strategies, Kerstin Voelz, Simon A. Johnston, and Robin C. May33. Pulmonary Innate and Adaptive Defenses against Cryptococcus, Kristi L. Williams, Floyd L. Wormley, Jr., Scarlett Geunes-Boyer, Jo Rae Wright, and Gary B. Huffnagle34. Invasion of Cryptococcus into the Central Nervous System, Francoise Dromer and Stuart M. Levitz35. Cryptococcosis in Experimental Animals: Lessons Learned, Karl V. Clemons and David A. Stevens36. Veterinary Insights into Cryptococcosis Caused by Cryptococcus neoformans and Cryptococcus gattii, Richard Malik, Mark B. Krockenberger, Carolyn R. O'Brien, Dee A. Carter, and Wieland MeyerVII. DIAGNOSIS, TREATMENT, PREVENTION, AND CLINICAL PERSPECTIVES37. Cryptococcosis in Transplant Recipients, Nina Singh and Barbara D. Alexander38. Cryptococcosis in AIDS, Bettina C. Fries and Gary M. Cox39. Antifungal Trials: Progress, Approaches, New Targets, and Perspectives in Cryptococcosis, Peter G. Pappas40. Vaccines and Antibody Therapies from Cryptococcus neoformans to Melanoma, Arturo Casadevall, Ekaterina Dadachova, and Liise-anne Pirofski41. Diagnostic Approach Based on Capsular Antigen, Capsule Detection, ss-Glucan, and DNA, Mara R. Diaz and M. Hong Nguyen42. Management of Cryptococcal Meningoencephalitis in Both Developed and Developing Countries, Joseph N. Jarvis, Tihana Bicanic, and Thomas S. Harrison43. Public Health Importance of Cryptococcal Disease: Epidemiology, Burden, and Control, Benjamin J. Park, Shawn R. Lockhart, Mary E. Brandt, and Tom M. Chiller44. Clinical Perspectives on Cryptococcus neoformans and Cryptococcus gattii: Implications for Diagnosis and Management, Tania C. Sorrell, Sharon C.-A. Chen, Peter Phillips, and Kieren A. Marr
