Full Description
A comprehensive examination of these fascinating proteins.Covers the basic molecular mechanisms of superantigen action, their structure and function, and their role in human diseases. Explains the clinical consequences of superantigen intoxication and the latest therapeutic interventions to combat superantigen toxicity. Emphasizes how newly discovered structural variations among superantigens affect their interactions with human immune cells. Most importantly, these structural and functional differences help explain the exacerbation of certain diseases and why certain superantigens are more effective in some tissues and not in others. Discusses the potential for the use of superantigens in bioterrorism. Serves as essential reading for researchers in the fields of microbiology, immunology, biotechnology, molecular medicine, and clinical infectious disease.This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of ContentsSection I. Superantigens: What is New?1. The Streptococcal Superantigens, John D. Fraser and Thomas Proft2. Staphylococcal and Streptococcal Superantigens: an Update (Patrick M. Schlievert and Gregory A. Bohach3. Mycoplasma arthritidis-Derived Superantigen (MAM), a Unique Class of Superantigen That Bridges Innate and Adaptive Immunity, Barry C. Cole and Hong-Hua Mu4. Viral Superantigens in Mice and Humans, Albert K. Tai and Brigitte T. Huber5. Superantigens from Gram-Negative Bacteria and the Diseases That They Cause, Takehiko Uchiyama, Tohru Miyoshi-Akiyama, and Hidehiro UeshibaSection II. Superantigen Structure and Function6. Superantigen Architecture: Functional Decoration on a Conserved Scaffold, Vickery L. Arcus and Edward N. Baker7. Structural Evidence for Zinc and Peptide Dependence in Superantigen-Major Histocompatibility Complex Class II Interaction, Bjoern Walse8. Superantigens: Structure, Function, and Diversity, Matthew D. Baker and K. Ravi AcharyaSection III. Superantigens and Human Diseases9. Role of Superantigens in Skin Disease, Sang-Hyun Cho and Donald Y. M. LeungSection IV. Experimental Models for Superantigen-Mediated Diseases10. Pathogenetic Mechanisms and Therapeutic Approaches in Superantigen-Induced Experimental Autoimmune Diseases, Andrej Tarkowski11. Experimental Models of Superantigen-Mediated Neuropathology, Malte E. Kornhuber, Alexander Emmer, Kristina Gerlach, and M. S. Staege12. Novel Experimental Models for Dissecting Genetic Susceptibility of Superantigen-Mediated Diseases, Eva MedinaSection V. Therapeutic Interventions in Superantigen-Mediated Diseases13. Intravenous Immunoglobulin Therapy in Superantigen-Mediated Toxic Shock Syndrome, Anna Norrby-Teglund, Donald E. Low, and Malak Kotb14. Broad-Spectrum Peptide Antagonists of Superantigen Toxins, Revital Levy, Iris Nasie, Dalia Hillman, Gila Arad, and Raymond Kaempfer15. Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock, Teresa Krakauer16. Countermeasures against Superantigens: Structure-Based Design of Bispecific Receptor Mimics, Goutam Gupta and Meghan Kunkel
