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基本説明
Presents a selection of chapters covering immunological aspects of infection. Examines the recent advances in the development of fungal vaccines.
Full Description
A compendium of research in the field of medical mycology. * Measures the impact of genome projects, genetics, and molecular biology on the understanding of a diverse group of pathogenic fungi and explores the potential impact of vaccines and new therapeutic approaches to treatment. * Provides a broad overview of pathogenic fungi, including ascomycetes, basidiomycetes, zygomycetes, and both rare and common infections. * Focuses on immunological aspects of infection involving innate, humoral, and cell-mediated immunity. * Features comprehensive coverage of everything from general principles to specific pathogens and vaccine development. * Offers an in-depth analysis of the host-pathogen relationship, and comtemplates future directions. * Serves as a valuable resource for students, fellows, instructors, researchers, specialists, clinicians, and anyone interested in the general field of microbial pathogenesis. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of ContentsI. General Principles1. Fungal Molecular Pathogenesis: What Can It Do and Why Do We Need It? John R. Perfect and Arturo Casadevall2. Sex, MAT, and the Evolution of Fungal Virulence, James A. Fraser and Joseph Heitman3. Post-Genomic Strategies for Genetic Analysis: Insight from Saccharomyces cerevisiae and Candida albicans, Clarissa J. Nobile and Aaron P. Mitchell4. Candida albicans Hypha Formation and Virulence, Paula Sundstrom5. The Conversion from Classical Studies in Fungal Pathogenesis to the Molecular Era, Kyung J. Kwon-Chung and Brian L. Wickes6. Mating and Parasexual Genetics in Candida albicans, Matthew Miller and Alexander Johnson7. The Mating-Type Locus and Mating of Candida albicans and Candida glabrata, David R. Soll8. Evolution of Human Pathogenic Fungi: Phylogenies and Species, John W. Taylor9. Establishment of Cell Identity in Pathogenic Fungi, Christina M. Hull10. Signal Transduction in the Interactions of Fungal Pathogens and Mammalian Hosts, Malcolm Whiteway and Catherine Bachewich11. Function and Regulation of Adhesin Gene Families in Saccharomyces cerevisiae, Candida albicans, and Candida glabrata, Irene Castano, Alejandro De Las Penas, and Brendan P. Cormack12. Fungal Biofilms: Agents of Disease and Drug Resistance, Gordon Ramage, Mahmoud A. Ghannoum, and Jose L. Lopez-Ribot13. Molecular Basis of Fungal Adherence to Endothelial and Epithelial Cells, Scott G. Filler, Donald C. Sheppard, and John E. Edwards, Jr.14. Molecular Principles of Antifungal Drug Resistance, Dominique Sanglard and Theodore C. WhiteII. Model Systems: Heterologous Hosts, Model Pathogens, and Fungal-Bacterial Interactions15. Heterologous Hosts and the Evolution and Study of Fungal Pathogenesis, Eleftherios Mylonakis, Stephen B. Calderwood, and Frederick M. Ausubel16. Amoeba and Slime Mold: Hosts of Virulence Evolution, Arturo Casadevall17. Aspergillus nidulans: a Model for Elucidation of Aspergillus fumigatus Secondary Metabolism, Nancy Keller18. Saccharomyces cerevisiae: an Emerging and Model Pathogenic Fungus, John H. McCusker19. Fungal-Bacterial Interactions, Deborah A. Hogan and Roberto Kolter20. Amphibian Chytridiomycosis as an Emerging Infectious Disease of Wildlife: What Can We Learn from the Earliest Diverging Fungi? Timothy Y. James and Rytas VilgalysIII. Specific Pathogens21. Cryptococcus neoformans: a Sugar-Coated Killer, John R. Perfect22. Towards a Molecular Understanding of Candida albicans Virulence, Frank C. Odds, Neil A. R. Gow, and Alistair J. P. Brown23. Molecular Determinants of Histoplasma capsulatum Pathogenesis, Jon P. Woods24. Molecular Determinants of Virulence in Aspergillus fumigatus, Judith C. Rhodes and Axel A. Brakhage25. Pathogenesis of Pneumocystis, A. George Smulian and Melanie T. Cushion26. Virulence Mechanisms of Coccidioides, Garry T. Cole, Jianmin Xue, Kalpathi Seshan, Priscila Borra, Ricardo Borra, Eric Tarcha, Ruth Schaller, Jie-Juen Yu, and Chiung-Yu Hung27. Blastomyces dermatitidis Cell Surface Determinants and Their Application in Vaccine Development, Bruce Klein28. Virulence Factors in Black Molds with Emphasis on Melanin, Chitin, and Wangiella as a Molecularly Tractable Model, Paul J. Szaniszlo29. Zygomycetes as Agents of Infectious Disease in Humans, Ashraf S. Ibrahim and Brad Spellberg30. Signaling Pathways in the Dimorphic Human Fungal Pathogen Penicillium marneffei, Alex Andrianopoulos and Sophie ZuberIV. The Host31. Innate Humoral Immunity to Fungi, Thomas R. Kozel32. Innate and Acquired Cellular Immunity to Fungi, Luigina Romani33. Acquired Antibody-Mediated Immunity to Fungi, Liise-Anne Pirofski and Arturo Casadevall34. Site-Specific Mucosal Immunity to Fungi: Lessons Learned from Candida albicans Applied to Other Fungi, Paul L. Fidel, Jr., and Beatriz Finkel-Jimenez35. Intracellular Pathogenesis of Histoplasma capsulatum, Simon L. Newman36. Interactions of Immune Cells with the Facultative Intracellular Pathogen Cryptococcus neoformans, Lauren E. Yauch and Stuart M. Levitz37. Fungal Interactions with Leukocytes, Mairi C. Noverr, Dennis M. Lindell, Galen B. Toews, and Gary B. Huffnagle38. Fungal Vaccine Development, Joshua D. Nosanchuk and George S. Deepe, Jr.39. Molecular Immunopathogenesis of Innate Host Defense against Chronic Disseminated (Hepatosplenic) Candidiasis, Thomas J. Walsh, Emmanuel Roilides, Karoll Cortez, and Caron LymanV. Future Directions40. Studying Fungal Virulence Using Genomics, Michael C. Lorenz41. Future of Functional Genomics of Histoplasma capsulatum, Anita Sil and Lena Hwang42. Functional Genomic Approaches to Fungal Pathogenesis, Drug Target Validation, and Antifungal Drug Discovery, Ainslie B. Parsons, Howard Bussey, and Charles Boone43. Genetic and Proteomic Analysis of Fungal Virulence, Jennifer K. Lodge and Michael C. Lorenz44. Genomic Perspectives on the Fungal Kingdom, Jason E. Stajich and Fred S. Dietrich
