生物情報学の方法：オミックスから次世代シークエンシングまで Bioinformatics Methods : From Omics to Next Generation Sequencing (Chapman & Hall/crc Computational Biology Series)

Lin, Shili/ Scholtens, Denise/ Datta, Sujay

Chapman & Hall/CRC（2022/09発売）

• 製本 Hardcover:ハードカバー版／ページ数 336 p.
• 言語 ENG
• 商品コード 9781498765152
• DDC分類 570.285

Full Description

The past three decades have witnessed an explosion of what is now referred to as high-dimensional `omics' data. Bioinformatics Methods: From Omics to Next Generation Sequencing describes the statistical methods and analytic frameworks that are best equipped to interpret these complex data and how they apply to health-related research. Covering the technologies that generate data, subtleties of various data types, and statistical underpinnings of methods, this book identifies a suite of potential analytic tools, and highlights commonalities among statistical methods that have been developed.

An ideal reference for biostatisticians and data analysts that work in collaboration with scientists and clinical investigators looking to ensure rigorous application of available methodologies.

Key Features:

Survey of a variety of omics data types and their unique features
Summary of statistical underpinnings for widely used omics data analysis methods
Description of software resources for performing omics data analyses

Contents

1 The Biology of a Living Organism 2 Protein-Protein Interactions 3 Protein-Protein Interaction Network Analyses 4 Detection of Imprinting and Maternal Effects 5 Modelling and Analysis of Next-Generation Sequencing Data 6 Sequencing-Based DNA Methylation Data 7 Modelling and Analysis of Spatial Chromatin Interactions 8 Digital Improvement of Single Cell Hi-C Data 9 Metabolomics Data Pre-processing 10 Metabolomics Data Analysis 11 Appendix