Full Description
This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances.
Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.
Contents
Introduction to Toxicologic Pathology.- The Pathology Report, Peer Review, and Pathology Working Group.- Routine and Special Techniques in Toxicologic Pathology.- Pathology of the Liver and Gallbladder.- Pathology of the Gastrointestinal Tract and Exocrine Pancreas.- Pathology of the Urinary System.- Pathology of the Nervous System.- Pathology of the Cardiovascular System.- Pathology of the Respiratory System.- Pathology of the Lymphoid System.- Pathology of the Male and Female Reproductive System and Mammary Gland.- Pathology of the Integumentary System.- Pathology of the Endocrine System.- Pathology of Bone, Skeletal Muscle, and Tooth.- Pathology of the Eye.- Pathology of the Ear.- Principles of Toxicologic Clinical Pathology.- Carcinogenicity.- Pathology of Juvenile Animals.- Non-Mammalian Laboratory Species: Fish, Frogs, and Beyond.- Appendix: Fundamental Pathology Terminology Based on the Standard for the Exchange of Nonclinical Data (SEND).
