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Full Description
This book describes the use of modern micro- and nanofabrication technologies to develop improved tools for stimulating and recording electrical activity in neuronal networks. It provides an overview of the different ways in which the "nano-world" can be beneficial for neuroscientists, including improvement of mechanical adhesion of cells on electrodes, tight-sealed extracellular recordings or intracellular approaches with strongly reduced invasiveness and tools for localized electrical or optical stimulation in optogenetics experiments. Specific discussion of fabrication strategies is included, to provide a comprehensive guide to develop micro and nanostructured tools for biological applications. A perspective on integrating these devices with state-of-the-art technologies for large-scale in vitro and in vivo experiments completes the picture of neuronal interfacing with micro- and nanostructures.
Contents
Nanotechnology and Neuroscience: nano-electronic, photonic and mechanical neuronal interfacing.- Carbon nanotubes for neuron-electrode interface with improved mechanical performance.- Nanoscale field-effect transistors for minimally invasive, high spatial resolution and three-dimensional action potential recording.- In-cell recording and stimulation by engulfment mechanisms.-Micromachining Techniques for Realization of Three-Dimensional Microelectrode Arrays.- Focused ion beam technology as a fabrication and inspection tool in neuron interfacing.- Active Pixel Sensor Multi Electrode Array for high spatio-temporal resolution.- Multi electrode and multi transistor arrays for in vivo recording.- Optogenetics.
