Full Description
This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non-Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately due to considerable advances in genomic and epigenomic approaches to study the origins of human disease. The editors will focus not only on describing epigenetic characteristics, mechanisms and results, but also on how considerations of epigenetics can alter interpretation and analysis of risks for complex traits. This book will be a resource for those who have been working in human genetics or analysis of human genetic data and are studying the impact of epigenetics on inheritance. An overview will be given of the impacts of inter-individual variation in epigenetic states from major changes (errors in genomic imprinting) that cause congenital developmental defects to subtle changes and their impact on complex traits. The editors will discuss the relationship between epigenetic changes and genetic changes in human disease. Several chapters will also focus on statistical analysis of epigenetics effects, either in human disease genetic studies, or in population genetics.
Contents
Part I: Epigenetic phenomena in the germ line and early embryonic development and their effects on the inheritance of genetic traits.- Epigenetic reprogramming in the mammalian germ line.- Establishment of tissue-specific epigenetic states during development.- X-chromosome Inactivation.- Cis- and trans-effects underlying polar overdominance at the callipyge locus.- Transgenerational epigenetic effects and complex inheritance patterns.- Autosomal monoallelic expression.- Part II: Epigenetic variation in health and disease.- Recurrent CNVs in the etiology of epigenetic neurodevelopmental disorders.- Impact of the early-life environment on the epigenome and behavioral development.- Interaction between genetics and epigenetics in cancer.- Part III: Impact of epigenetics on complex trait genetics and analysis.- Epigenetic variation, phenotypic heritability, and evolution.- Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans.- Transmission ratio distortion: a neglected phenomenon with many consequences in genetic analysis and population genetics.- Epigenome Wide Association Studies: Potential insights into human disease.- Analytical Considerations for Epigenome-wide Association Scans of Complex Traits.- Index.
