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Full Description
This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories.
Written by leading researchers in their fields, Studies on Psychiatric Disorders explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants—in particular polyphenols, ω-3 fatty acids orcombination of both—could be effective for long-term treatment of some neuropsychiatric disorders.
Contents
1. Oxidative nitrative and chlorinative stress: biomarkers.- Part 1. Clinical aspects.- 2. Oxidative stress in schizophrenia.- 3. Oxidative stress in bipolar disorders.- 4. Contribution of oxidative stress to the pathophysiology of autism spectrum disorders: Impact of genetic and environmental factors.- 5. Oxidative stress and anxiety disorder.- 6. The relationship between oxidative stress and obsessive- compulsive disorder.- 7. A relationship between oxidative status and attention deficit hyperactivity disorder.- 8. The role of oxidative stress in neurodegenerative diseases.- Part 2. Pathophysiological aspects.- 9. Magnetic resonance spectroscopy studies in Bipolar Disorder patients: Focus on the potential role of oxidative stress.- 10. The impact of oxidative stress on dopaminergic neurotransmission.- 11. The reciprocal effects of oxidative stress and glutamate neurotransmission.- 12. Mitochondrial dysfunction in psychiatric disorders.- 13. The kynurenine pathway at the interface between neuroinflammation, oxidative stress and neurochemical disturbances: Emphasis in schizophrenia.- 14. Dysregulation of glutathione synthesis in psychiatric disorders.- 15. Role of nitrative stress in brain of schizophrenic patients.- 16. Blood platelet as a peripheral cell in oxidative stress in psychiatric diseases.- 17. Mitochondrial dysfunction in autism.- 18. Ultrasound and Autism: How Disrupted Redox Homeostasis and Transient Membrane Porosity Confer Risk.- 19. Animal Model of Autistic Regression: Link to Toxicant-Induced Oxidative Stress.- 20. Genetic Polymorphism Related to Oxidative Stress in Autism.- 21. Telomere length in major psychiatric disorders. Is there any relationship between telomere length and oxidative stress?.- 22. The impact of oxidative stress on GAD67 levels and parvalbumin - positive neurons.- 23. The possible role of iron in neurodegeneration.- 24. Oxidation stress and polyunsaturated lipid peroxidation products in the CNS: focus on DHA-derived fragment.- Part 3. Therapeutic aspects.- 25. Antioxidant interventions in neuropsychiatric disorders.- 26. Antioxidant plant polyphenols and cognitive disorders.- 27. Hyperbaric oxygen treatment in autism spectrum disorders.- 28. Effects of lithium on oxidative stress.- 29. Cryostimulation as adjunct treatment in psychiatric disorders.- Index.
