Full Description
Our goal is to develop automated methods for the segmentation of thr- dimensional biomedical images. Here, we describe the segmentation of c- focal microscopy images of bee brains (20 individuals) by registration to one or several atlas images. Registration is performed by a highly parallel imp- mentation of an entropy-based nonrigid registration algorithm using B-spline transformations. We present and evaluate different methods to solve the cor- spondence problem in atlas based registration. An image can be segmented by registering it to an individual atlas, an average atlas, or multiple atlases. When registering to multiple atlases, combining the individual segmentations into a ?nalsegmentationcanbeachievedbyatlasselection,ormulticlassi?erdecision fusion. Wedescribeallthesemethodsandevaluatethesegmentationaccuracies that they achieve by performing experiments with electronic phantoms as well as by comparing their outputs to a manual gold standard. The present work is focused on the mathematical and computational t- ory behind a technique for deformable image registration termed Hyperelastic Warping, and demonstration of the technique via applications in image regist- tion and strain measurement. The approach combines well-established prin- ples of nonlinear continuum mechanics with forces derived directly from thr- dimensional image data to achieve registration. The general approach does not require the de?nition of landmarks, ?ducials, or surfaces, although it can - commodate these if available. Representative problems demonstrate the robust and ?exible nature of the approach. Three-dimensional registration methods are introduced for registering MRI volumes of the pelvis and prostate. The chapter ?rst reviews the applications, xi xii Preface challenges,and previous methods of image registration in the prostate.
Contents
Medical Image Registration: Theory, Algorithm, and Case Studies in Surgical Simulation, Chest Cancer, and Multiple Sclerosis.- State of the Art of Level Set Methods in Segmentation and Registration of Medical Imaging Modalities.- Three-Dimensional Rigid and Non-Rigid Image Registration for the Pelvis and Prostate.- Stereo and Temporal Retinal Image Registration by Mutual Information Maximization.- Quantification of Brain Aneurysm Dimensions from CTA for Surgical Planning of Coiling Interventions.- Inverse Consistent Image Registration.- A Computer-Aided Design System for Segmentation of Volumetric Images.- Inter-Subject Non-Rigid Registration: An Overview with Classification and the Romeo Algorithm.- Elastic Registration for Biomedical Applications.- Cross-Entropy, Reversed Cross-Entropy, and Symmetric Divergence Similarity Measures for 3D Image Registration: A Comparative Study.- Quo Vadis, Atlas-Based Segmentation?.- Deformable Image Registration with Hyperelastic Warping.- Future of Image Registration.
