Full Description
Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
Contents
Transmissible Spongiform Encephalopathy: from the High Middle Ages to Daniel Carlton Gajdusek.- The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein.- Role of Cellular Prion Protein in the Amyloid-ß Oligomer Pathophysiology of Alzheimer's Disease.- Cellular Prion Protein and Cancers.- Insoluble Cellular Prion Protein.- Protein Misfolding Cyclic Amplification.- Cofactor Involvement in Prion Propagation.- Prion Protein Conversion and Lipids.- New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating.- Infectious and Pathogenic Forms of Prion Protein.- Cellular Mechanisms of Propagation and Clearance.- Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains.- Modeling the Cell Biology of Prions.- Prion Strain Interference.- Introduction to Yeast and Fungal Prions.- Yeast Prions are Pathogenic, in-register Parallel Amyloids.
