Full Description
The NATO Advanced Studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in Cape Sounion, Greece, in which the present and the future of this important area of research in drug delivery is discussed in great depth. Previous ASIs of the series dealt with drug carriers of natural and synthetic origin, their interaction with the biological milieu, ways by which the latter influences such interaction, strategies by which milieu interference curtailing the function of drug carriers is circumvented and, more recently, with the application of drug carriers for the delivery of peptides and proteins. The present book contains the of the 7th NATO ASI "Targeting of Drugs: Advances in System Constructs", proceedings held in Cape Sounion during 24 June -5 July 1993. As the title implies, the book deals with a variety of approaches to carrier design or modification that contribute to optimal carrier function. to Mrs Concha Perring for her assistance with the We express our appreciation organization of the ASI. We thank Dr. G. Deliconstantinos who, as chairperson of the Local Committee, contributed to the success of the Institute. The ASI was held under the sponsorship of NATO Scientific Affairs Division and co-sponsored and generously financed by SmithKline Beecham Pharmaceuticals (King of Prussia). Financial assistance was also provided by Liposome Technology Inc. (Menlo Park), Vestar Inc. (San Dimas) and Zeneka (Macclesfield).
Contents
Drug targeting with glycoproteins and other peptide carriers: An overview.- Sugar specific delivery of drugs, oligonucleotides and genes.- The use of MSH derivatives for targeting to melanomas.- The immunogenicity of recombinant proteins and of "magic bullets" represents the main obstacle for the effective in vivo targeting of biologic response modifiers (BRMs).- Targeting of drugs to tumors: The use of the plasminogen activator inhibitor as a ligand.- Advances in diagnosis and treatment of neoplasia using radioactive monoclonal antibodies.- Targeting transcription factors to inhibit selectively gene expression in particular cell types.- Design, biological properties and delivery of antisense oligonucleotides.- Liposomes in vivo: Control of behaviour.- Passive targeting of anthracyclines entrapped in long-circulating(Stealth) liposomes in the treatment of cancer.- Liposomal drug delivery: possibilities for manipulation.- Polysialic acids: In vivo properties and possible uses in drug delivery.- Red blood cells as carriers of drugs against retroviruses.- Nanoparticles for the delivery of peptides and proteins.- New poly(methylidene malonate 2.1.2) nanoparticles: Recent developments.- Oral uptake and translocation of nanoparticles: A real but useful phenomenon?.- Particulate systems for site specific drug delivery.- Participant's Photograph.- Contributors.
