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Full Description
One of the fundamental concepts of toxicology is that chemicals act at selective receptors and that such interactions result in phar macologic responses which, depending on dose, mayor may not result in toxicity. For us to understand how insecticides produce their toxic effects, we must first understand their molecular interactions with their target receptors. With this in mind, we organized a symposium which was given in conjunction with the XVII International Congress of Entomology in Hamburg on August 21, 1984. The goal of this symposium was to bring together researchers with a wide range of expertise who shared a common interest in the action of insecticides on the insect nervous system. It was decided to restrict the scope of the symposium so that selected topics could be discussed in greater depth. The volume which resulted from this symposium, -Membranes Receptors and Enzymes as Targets of Insecticidal Action-, details a number of bio chemical modes of action of insecticides on the insect nervous system. The volume is divided into two sections; the first dealing with the action of insecticides on the GABA-ch1oride channel complex. This section evolves from a discussion of the symptoms of cyclodiene toxicity presented by Dr. D. E. Woolley, to the structure-activity relationships and pharmacology of the channel complex and is concluded with the extremely interesting work of Dr. C. C. Wang on the action(s) of avermectin at this receptor.
Contents
GABA-Chloride Channel Complex and Insecticidal Action.- Effects and Proposed Mechanisms of Action of Lindane in Mammals: Unsolved Problems.- Altered Picrotoxinin Receptor as a Cause for Cyclodiene Resistance in Musca domestica, Aedes aegypti and Blattella germanica.- Acetylcholine and GABA Receptors in Insect CNS as Sites of Insecticide Action.- Bridged Bicyclic Organophosphorus Compounds as a Probe for Toxicological Study on GABA Synapse.- The GABA/Benzodiazepine Receptor · Chloride Channel: Biochemical Identification in Insects and Stereospecific Binding of Insecticides.- The Effect of Avermectins on Invertebrate GABA Nervous Systems.- Neurochemestry, Neurophysiology and Insecticidal Action.- The Effects of Insecticides on Neurosecretory Processes in Insects.- Cyclic AMP Synthesis and Degradation: Possible Targets for Pesticide Action.- On Inhibitory Action of DDT and Pyrethroids on ATP-Utilizing, Calcium Transporting Systems in Neural Tissues.- Action of Pyrethroids on Ca2+-Stimulated ATP Hydrolyzing Activities: Protein Phosphorylation-Dephosphorylation Events in Insect Brain Fractions.- The Nicotinic Acetylcholine Receptor: Molecular Aspects and Interactions with insecticides.- The Action of Glutamate Agonist at Insect Neuromuscular Junctions.
