Full Description
The ever-expanding research on human cancer has resulted in numerous technical and conceptual advances during the last few years. Serological, structural, and biological char acterization of human melanoma constitutes one area of research that has received consid erable attention from researchers and clinicians and has generated new and exciting infor mation. In this volume, we have attempted to assemble work on topics that produced some of the most recent advances. We asked each author to describe and interpret his most cur rent research and, whenever possible, to compare and contrast it with work of other inves tigators in the field. We have been careful not to impose our viewpoints except in contri butions from our own laboratories, since we want to provide the reader with as many divergent and sometimes opposing viewpoints as feasible. Therefore, we have not been overly concerned with overlaps in some individual topics. We hope that this volume will provide the reader with a well-balanced overview of current problems and ideas in a par ticular area of cancer research. We wish to express our thanks to all contributors for their timely and very interesting manuscripts, and we sincerely hope that the reader will enjoy this volume and benefit as much from it as we did. R. A. Reisfeld S. Ferrone La Jolla ix Contents CHAPTER 1 Immunogenetics of Melanoma RONALD T. ACTON, CHARLES M. BALCH, BRUCE BUDOWLE, RODNEY C. P. Go, JEFFREY M. ROSEMAN, SENG-jAW SOONG, AND BRUCE O. BARGER 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Contents
1 Immunogenetics of Melanoma.- 2 Indomethacin, Prostaglandin, and Immune Regulation in Melanoma.- 3 Shedding and Degradation of Cell-Surface Macromolecules and Melanoma-Associated Antigens by Human Melanoma.- 4 Monoclonal Antibodies as a Tool to Detect Melanoma-Associated Antigens.- 5 Tumor-Directed Cellular Immunity in Malignant Melanoma and the Antigens That Evoke It.- 6 Heterogeneity of Human Melanoma-Associated Antigens Revealed by Alloantisera and Xenoantisera.- 7 Protein Antigens of Mouse Melanomas.- 8 Clinical Significance of Tumor-Associated Antigens and Antitumor Antibodies in Human Malignant Melanoma.- 9 Specificity of Cell-Mediated Immunoreactivity in Melanoma and Comments on the Nature of Serum Blocking Factors.- 10 Antigens in Human Melanomas Detected by Using Monoclonal Antibodies as Probes.- 11 The Nature and Significance of Melanoma Antigens Recognized by Human Subjects.- 12 Cellular and Humoral Studies of Malignant Melanoma.- 13 Immunodiagnosis of Human Melanoma: Detection of Circulating Melanoma-Associated Antigens by Radioimmunoassay.- 14 The Association between Antigens of Human Malignant-Melanoma Cells and Mycobacterium bovis (BCG).- 15 Monoclonal Antibodies to Human Melanoma-Associated Antigens: Elicitation and Evaluation with Immunochemically Defined Antigen Preparations.- 16 The Significance of Circulating Immune Complexes in Patients with Malignant Melanoma.- 17 Molecular and Immunological Characterization of Human Melanoma-Associated Antigens.- 18 Cell-Surface Structure and State of Malignancy in Human Malignant Melanoma.- 19 Immunotherapy of Melanoma.- 20 Biological Studies of Antimelanoma Monoclonal Antibodies.- 21 The Features of Malignant Melanoma Organ-Specific Neoantigens Recognized by the Antitumor Immune Response of the Human Host.- 22Immunochemical Analysis of the Antigenic Profile of Human Melanoma Cells with Monoclonal Antibodies.
