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Full Description
The topic of nucleosome dynamics is of exceptional current interest in a number of subfields of modern biology, including molecular biology, structural biology, cell biology, systems biology and biophysics. Changes in nucleosome structure are necessary to regulate DNA repair and for the regulation and transcription in eukaryotes. This book brings together research advances made over the last ten years to provide a comprehensive reference on nucleosome dynamics and remodeling and their role in gene regulation.Key selling Features:Reviews Nucleosome Dynamics, an expanding research area, in a systematic and comprehensive mannerRelates positioning to epigenetics and to the regulation of physiological processesIncludes the contributions of authors who have many years of experience in the field and who generated the first high-resolution genome-wide map of H2A.Z nucleosome positions in DrosophilaOffers a text for which there currently is no direct competitionProvides current research on the interaction between transcription factors, nucleosomes and chromatin remodeling enzymes
Contents
Overview of nucleosome. Histone variants and their roles. Nucleosome organization in the genome and gene transcription. Dynamics of nucleosome positioning. Nucleosome positioning mechanisms. In vitro nucleosome assembly. Nucleosome turnover and split. Histone modifications and their function. Interplay between transcription factor binding and nucleosome organization. High-throughput technologies in nucleosome remodeling study.
