Full Description
Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Contents
Introduction and History of Controlling Drug Release.- The Organization of the Gut and the Oral Absorption of Drugs: Anatomical, Biological and Physiological Considerations in Oral Formulation Development.- Controlling Drug Release in Oral Product Development Programs: An Industrial Perspective.- Animal Model Systems Suitable for Controlled Release Modeling.- In Vitro Testing of Controlled Release Dosage Forms during Development and Manufacture.- Oral Controlled Delivery Mechanisms and Technologies.- Drug-Polymer Matrices for Extended Release.- Ion Exchange Approaches to Controlling Drug Release.- Pulsatile Delivery for Controlling Drug Release.- Ordered Mesoporous Silica for the Delivery of Poorly Soluble Drugs.- Geometric Release Systems: Principles, Mechanisms, Kinetics, Polymer Science, Release Modifying Materials.- Extrudable Technologies for Controlling Drug Release and Absorption.- Coated Multiparticulates for Controlling Drug Release.- Capsules as a Delivery System for Modified Release Products.- Lipids in Oral Controlled Release Drug Delivery.- Buccal Drug Delivery.- Controlling Release by Gastro Retention.- Drug Delivery to the Colon.
