Full Description
In Cushing's Disease, leading authorities in the field offer a thorough review of the pathogenesis, diagnostic algorithm and treatment options for this complex disease. Beginning with a fascinating history of Cushing's disease that outlines its historical significance to both endocrinology and neurosurgery, the book goes onto to cover the full range of important issues, including the molecular pathogenesis of Cushing's, anatomic pathology, the diagnosis of Cushing's syndrome, the differential of pseudo-Cushing's syndromes, hypercortisolemia, surgical removal of the corticotroph adenoma, post-operative management and assessment of remission, radiotherapeutic options, and the exciting developments in medical therapy. In addition, the book also addresses Cushing's disease in the pediatric population, given that its clinical manifestations and impact on growth can be severe; silent corticotroph adenomas as a distinct clinical entity; diagnosis and management of Cushing's disease during pregnancy, bilateral adrenalectomy, and, finally, the long-term psychological manifestations of hypercortisolemia. Comprehensive and an invaluable addition the literature, Cushing's Disease is an essential reference for enhancing diagnosis and treatment of this debilitating disorder.
Contents
History.- Molecular Biology of Cushing's.- Pathology.- Clinical Diagnosis of Cushing's Syndrome (including Hormone Testing).- Clinical Applications of Statistical Analysis of Test Results.- Pseudo-Cushing's Syndromes.- Cyclical Cushing's.- Differential Dx of Cushing's Disease: Locating the Source of Hormone Excess.- Pituitary Imaging.- Surgical Treatment.- Postop Management and Assessment of the Cure.- Radiation Treatment.- Medical Management (including Tumor Suppressive Agents, Dopamine Agonists, etc).- Treatment of Recurrent Disease.- Pediatric Cushing's.- Silent Corticotroph Adenomas.- Cushing's and Pregnancy.- Nelson's Syndrome.- Index.
