Full Description
This volume of Cerebral Cortex is dedicated to Sir John Eccles, who was an active member of the advisory board for the series until his death in May 1997. His input as to what topics should be covered in future volumes of this series will be sorely missed. The present volume is concerned with neurodegenerative disorders and age related changes in the structure and function of the cerebral cortex, a topic that has attracted increasing interest as longevity and the number of aged individuals in the population increase. Although much of the research on the neurodegenerative effects of aging has been centered on Alzheimer's disease, most of the aging popu lation will not be afflicted by this disease. They will, however, be affected by the consequences of normal aging, so the first few chapters of this volume are con cerned with that topic. Chapter 1, by Marilyn S. Albert and Mark B. Moss, gives an account of the cognitive changes that accompany normal human aging. Chapter 2, by Mark B.
Contents
1 Cognitive Profiles of Normal Human Aging.- 2 Age-Related Cognitive Decline in the Rhesus Monkey.- 3 Normal Aging in the Cerebral Cortex of Primates.- 4 Age-Related Neuronal Loss in the Cerebral Cortex.- 5 Age-Related Cognitive Deficits and Neurotransmitters: The Role of Catecholamine Mechanisms in Prefrontal Cortical Cognitive Decline.- 6 Neurotransmitter Receptor Changes in the Hippocampus and Cerebral Cortex in Normal Aging.- 7 Trophic Factors in Experimental Models of Adult Central Nervous System Injury.- 8 Cortical Neuropathology in Aging and Dementing Disorders: Neuronal Typology, Connectivity, and Selective Vulnerability.- 9 The Anatomy of Dementias.- 10 Age-Related Changes in Subcortical Nuclei that Project to the Cerebral Cortex.- 11 Ultrastructural Changes in Dementing Illnesses.- 12 Locating Genetic Modifiers for Inherited Neurodegenerative Diseases.- 13 Early Features of Alzheimer's Disease.- 14 Temporal Sequence of Alzheimer's Disease-Related Pathology.- 15 Neuropathological Correlates of Dementia in Alzheimer's Disease.- 16 Multifocal Cortical Neurodegeneration in Alzheimer's Disease.- 17 Molecular Pathology of Alzheimer's Disease and Related Disorders.- 18 Glutamate Receptors and Excitotoxic Mechanisms in Alzheimer's Disease.- 19 Nerve Growth Factor Systems in Alzheimer's Disease.- 20 Vascular-Related and Mediated Alterations in Alzheimer's Disease.
