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Full Description
This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf ing from cell membranes to intracellular compartments and the nucleus is becoming in creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).
Contents
1. Introductory Remarks: Historical Roots and Contemporary Aspects of Lipoxygenase Research.- I: Enzymology, Molecular Biology, and Biological Functions of Mammalian Lipoxygenases.- 2. Mammalian 15-Lipoxygenases: Enzymatic Properties and Biological Implications.- 3. Molecular Cloning of a Second Human 15S-Lipoxygenase and Its Murine Homologue, an 8S-Lipoxygenase: Their Relationship to Other Mammalian Lipoxygenases.- 4. Arachidonate 12-Lipoxygenase Isozymes.- 5. Expression of Leukocyte-Type 12-Lipoxygenase and Reticulocyte-Type 15-Lipoxygenase in Rabbits.- 6. Lipoxygenase Gene Disruption Studies: Status and Applications.- II: Metabolic Regulation of Lipoxygenases: Lipoxygenase Inhibitors.- 7. The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain.- 8. Biological Relevance of the 12-Lipoxygenase Pathway for Platelet and Lymphocyte Functions.- 9. Effect of 15-HETE on the 5-Lipoxygenase Pathway in Neutrophils: Genuine Inhibitor or Alternative Substrate?.- 10. Adenosine: An Endogenous Inhibitor of Arachidonic Acid Release and Leukotriene Biosynthesis in Human Neutrophils.- 11. Pharmacological Aspects of 5-Lipoxygenase Inhibition.- III: Products of the Lipoxygenase Pathways and Their Receptors.- 12. The Hepoxilins: A Review.- 13. Aspirin-Triggered 15-Epi-Lipoxin A4 and Stable Analogs of Lipoxin A4 Are Potent Inhibitors of Acute Inflammation: Receptors and Pathways.- 14. Modulation of LTB4 Receptor in T-Lymphocytes by Lipoxin A4 (LXA4) and Its Role in Delayed-Type Hypersensitivity.- 15. Receptors for Cysteinyl-Leukotrienes in Human Cells.- 16. Cysteinyl-Leukotrienes and the Human Lung.- 17. 12(S)-HETE in Cancer Metastasis.- 18. A 12(S)-EETE Receptor in Lewis Lung Carcinoma Cells.- 19. Fatty Acids, Eicosanoids, and Hypolipidemic Agents Regulate Gene Expression through Direct Binding to Peroxisome Proliferator-Activated Receptors.- 20. Biogenesis and Biological Function of Marine Algal Oxylipins.- Contributors.
