Full Description
What justifies the size of this compendium of reviews on the paramyxoviruses? As intracellular parasites that reproduce with almost complete indifference to nuclear activities, paramyxoviruses have not been providing insights about genes that regulate cellular activities and development, topics that account for much of the excitement in modem biology. For contributions of virus research to those topics, we must look to the retroviruses, which have the propensity to steal developmentally important genes and subvert them to malignant pur poses, and to the nuclear DNA viruses, whose gene expression depends heavily upon cellular transcription machinery, making them exceptionally useful tools for identifying and characterizing components of that machinery. From this perspective, it may appear that purely lytic viruses like the paramyxoviruses are sitting on the sidelines of contemporary biology. But there is plenty of action on the sidelines. Paramyxoviruses remain unconquered, devastating agents of disease. Human deaths attributable to paramyxoviruses worldwide, especially in children, are numbered in the mil lions annually. There are many pathogenic paramyxoviruses and too few effec tive vaccines, and those vaccines (against measles and mumps) are affordable only by relatively affluent nations. Moreover, the paramyxoviruses are intrin sically interesting organisms, presenting the challenge of understanding the self-replication of RNA and many other challenges peculiar to the structures and functions of their proteins, not only as individual entities, but also as they act in concert during virus reproduction and interact with vital functions of the cells they infect and often (but not always) destroy.
Contents
1 The Genetics of Paramyxoviruses.- 2 The Molecular Biology of the Paramyxovirus Genus.- 3 The Molecular Biology of the Morbilliviruses.- 4 The Molecular Biology of Human Respiratory Syncytial Virus (RSV) of the Genus Pneumovirus.- 5 Evolutionary Relationships of Paramyxovirus Nucleocapsid-Associated Proteins.- 6 The Nonstructural Proteins of Paramyxoviruses.- 7 Paramyxovirus RNA Synthesis and P Gene Expression.- 8 Function of Paramyxovirus 3? and 5? End Sequences: In Theory and Practice.- 9 The Role of Viral and Host Cell Proteins in Paramyxovirus Transcription and Replication.- 10 Deletion Mutants of Paramyxoviruses.- 11 Paramyxovirus Persistence: Consequences for Host and Virus.- 12 Molecular Biology of Defective Measles Viruses Persisting in the Human Central Nervous System.- 13 Structure, Function, and Intracellular Processing of the Glycoproteins of Paramyxoviridae.- 14 The Unusual Attachment Glycoprotein of the Respiratory Syncytial Viruses: Structure, Maturation, and Role in Immunity.- 15 New Frontiers Opened by the Exploration of Host Cell Receptors.- 16 Paramyxovirus M Proteins: Pulling It All Together and Taking It on the Road.- 17 Intracellular Targeting and Assembly of Paramyxovirus Proteins.- 18 Immunobiology of Paramyxoviruses.- 19 Epidemiology of Paramyxoviridae.
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