Full Description
This volume contains the proceedings of the NATO Advanced Study Institute held in Porto Conte (Alghero), Sardinia, September 15-27, 1991. The A. S. 1. was attended by 86 graduate and postgraduate students from 18 different countries, and was hosted by the newly founded International Laboratory of Molecular Genetics of Porto Conte, directed by Prof. Marcello Siniscalco. The A. S. I. was funded by NATO Scientific Affairs Division, the International Union of Immunological Societies, the European Community (Directorate General for Science, Research and Development), the Italian Research Council, and the San Raffaele Institute of Milano. In addition, a number of students who reside in the U. S. received travel funds from the U. S. National Science Foundation, and the Turkish National Fund provided financial assistance to several students from Turkey. When we decided to organize a course on T lymphocytes, our concern was to reach a balance between the teaching of both the hard core principles and the latest experimental findings of cellular immunology, and the recently expanded interfaces with the not-yet known: hypotheses, speCUlations, new projections to be born from the discussions.
Contents
1 T-cell antigen and MHC recognition: Molecular analysis of human ?/? TCR specific for a tetanus toxin-derived peptide.- 2. Structure of the TCR-Ag-MHC complex.- 3. Is recognition by the T cell receptor highly constrained or very degenerate?.- 4. Characteristics of foreign and self eptides endogenously bound to MHC class I molecules.- 5. Positive and negative selection of T cells.- 6. Peripheral tolerance.- 7. The functional relationship between preferential use of newly synthesized class II molecules and their stable association with peptides.- 8. Epitope selection and autoimmunity.- 9. HLA-A2 allorecognition and subtyped diversification.- 10. On the antigenicity of antibody idiotypes.- 11. Idiotype interactions between T cells.- 12. A network of self interactions.- 13. Stimulation of lymphocytes by anti-idiotypes bearing the internal image of viral antigens.- 14. Cloned suppressor T cells -- their identity, functions and mediators.- 15. The autoreactive T cell receptor: Structure and biological activity.- 16. The relationship between diabetes and lymphopenia in the BB rat.- 17. RT6, an unusually polymorphic T cell specific membrane protein linked to type I autoimmune diabetes in rats and mice.- 18. Alternative pathways of signal transduction after ligation of the TCR by bacterial superantigen.- 19. Molecular analysis of the interactions between staphylococcal enterotoxin A superantigen and the human MHC class II molecules.- 20. Immunosuppression by MHC class II blockade.- 21. Recognition of HIV antigens by human T helper cells.- 22. Proliferative responses to the V3 region of HIV envelope are enhanced following immunization with V3:Ty virus-like particles in mice.- 23. Teaching immunology: a Montessori approach using a computer model of the immune system.- 24.Modelling T cell memory in vivo and in vitro.- 25. Oligoclonal T cells expressing the TCR V?6 gene product following IL-2 culture of ovarian carcinoma-derived lymphocytes.- 26. Comparisons of the V-delta-1 expressing T cells in synovial fluid and peripheral blood of patients with chronic arthritis.- 27. Bispecific monoclonal antibody-targeted cytotoxic T lymphocytes can recycle.
