Full Description
Neurovirology, the study of viral infection of the ner vous system, has evolved at the interface of three of the most rapidly unfolding fields of investigation-neurobiology, vi rology, and immunology. In all three, increasing knowledge about the molecular structure of surface receptors, how in tracellular messages are transmitted, and how diversity is regulated genetically is provided, along with the techniques of molecular biology. This promises to give us knowledge not only about the process of infection and the complex host and viral determinants of neuroinvasiveness and neurovirulence, but eventually it will provide the background from which to engineer vaccines and to devise novel therapeutic agents. Animal virology and molecular biology developed quite independently from different origins. Animal virology was originally the province of the pathologists, and by clinical observation and histological preparations, they tried to ex plain the incubation period, the pathways of virus spread, and the mechanisms of disease. Molecular virology grew out of biochemistry, particularly through studies of bacterio phage, with emphasis on the physical and chemical structure of viruses and the sequences of biochemical events during the replicative cycle in cells.
Contents
DNA Viruses.- 1 Herpes Simplex Viruses, Central Nervous System, and Encephalitis: A Two-Body Problem, with One Outcome and Too Many Questions.- 2 The Molecular Biology of JC Virus, Causative Agent of Progressive Multifocal Leukoencephalopathy.- RNA Viruses With DNA Step in Replication.- 3 Molecular Basis of Neurologic Disorders Induced by a Mutant, tel, of Moloney Murine Leukemia Virus.- 4 Pathogenesis of Murine Spongiform Myeloencephalopathy Induced by a Murine Retrovirus.- 5 Biological and Molecular Aspects of HTLV-1-Associated Diseases.- RNA Viruses with Positive-Sense Genome and No Dna Step in Replication.- 7 Molecular Mechanisms of Poliovirus Pathogenesis.- 8 Determinants of Neurological Disease Induced by Theiler's Murine Encephalomyelitis Virus.- 9 Molecular Basis of Neuropathogenicity of Mouse Hepatitis Virus.- 10 Sindbis Virus.- 11 Pathogenesis of Age-Dependent Poliomyelitis of Mice: Viral and Immunological Factors Contributing to Fatal Paralysis.- RNA Viruses with Negative-Sense Genome and No DNA Step in Replication.- 12 Molecular Aspects of Measles-Virus-Induced Central Nervous System Diseases.- 13 Molecular Approaches to the Study of Bunyavirus Encephalitis Francisco Gonzalez-Scarano.- Unconventional Agents.- 14 Molecular Biological Studies of Prion Disorders in Humans and Animals.- 15 Infectious Amyloidoses: Transthyretin Familial Amyloidotic Polyneuropathy as a Paradigm for Genetic Control of Spontaneous Generation of Transmissible Amyloids in CJD and Other Spongiform Encephalopathies.- A Challenge to Neurovirology: Human Immunodeficiency Virus and Aids.- 16 The Role of Human Immunodeficiency Virus Type 1 (H1V-1) in Neurologic Disorders of AIDS.
