Full Description
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the vast body of basic science and clinical data associated with adenomatous polyps of the colon, much of it inspired by the realization that most colorectal carcinomas seem to arise in such polyps. This book strives to evaluate these data, with particular emphasis on their implications for management of polyp-bearing subjects. Topics comprehensively explored include anatomy and histology of the normal colon; pathologic characteristics of adenomatous polyps, differential diagnosis, and grading schemes for degree of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic evidence for the malignant potential of adenomatous polyps; and detection and management, with special attention to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
Contents
Normal Colon.- A. Anatomic Considerations.- B. Histology.- Pathology.- A. General Prevalence and Anatomic Distribution.- B. Gross Appearance.- C. Microscopic Features.- D. Differential Diagnosis.- E. The Diminutive Polyp.- F. Other Characteristics of Polyps.- G. Histogenesis of Polyps.- Adenomatous Polyposes.- A. Familial Polyposis Coli and Gardner's Syndrome.- B. Other Adenomatous Polyposis Syndromes.- C. The Genetics of Adenoma Transmission.- Malignant Potential of Adenomatous Polyps.- A. Association of Polyps and Carcinomas.- B. Histological Evidence of Malignant Transformation.- C. Adenomatous Remnants in Carcinomas.- D. Epidemiological Evidence and Etiological Factors.- E. Findings in Experimental Animals.- F. Alternate Hypotheses of Carcinogenesis.- G. Conclusions.- Detection and Management.- A. Screening, Diagnostic, and Surveillance Techniques.- B. The Malignant Polyp.- C. Endoscopic Polypectomy.- D. Postpolypectomy Surveillance Recommendations.- E. The National Polyp Study.- F. Polyp Registries.- Conclusions.- Glossary and Abbreviations.
