Full Description
Translational medicine underpins vascular medicine. It is fundamental to understanding how we treat patients with vascular disease and more importantly, how to prevent it. It is the rationale for drug design and production. Vascular medicine and translational medicine will take over and become the main reason for referring patients to hospital. Therefore, hospital-based clinicians working with basic scientists need to know about translational medicine, which educates and informs them about vascular medicine and how management should be based.
This book is a primer for translational vascular medicine and discusses the evolving and exciting areas of basic science applied to vascular medicine. The book is based on the third vascular biology conference held at The Royal College of Physicians in 2008. It provides a large amount of new basic and clinical information and the contributors are world leaders.
Contents
Section 1 - Hot Topics in Vascular Biology.- 1. Pericytes: Adaptable vascular progenitors.- 2. Benefits and risks of manipulating the HIF hydroxylase pathway in ischaemic heart disease.- 3. Cytoprotective mechanisms in the vasculature.- 4. Notch signalling in vascular development .- Section 2 - Novel Molecular Mediators Regulating Cardiovascular System.- 5. The therpeutic potential of dimethylarginine dimethylaminohydrolase mediated regulation of nitric oxide synthesis..- 6. Potassium channels regulating the electrical activity of the heart.- 7. Free radicals oxidant stress and cardiovascular disease.- Section 3 - Clinical Aspects of Cardiovascular Disease.- 8. The Broken Heart Syndrome.- 9. Lymphatic endothelium in health and disease.- 10. Importance of sub-type selectivity for endothelin receptor antagonists in the human vasculature.- 11. Non-pharmacological treatment of PAD.- 12. Surgical Approaches to Abdominal Aortic Aneurysm Repair.- Section 4 - Clinical and translational Aspects of Pulmonary Vascular Disease.- 13. Understanding the pathobiology of pulmonary vascular disease.- 14. Inflammation in pulmonary arterial hypertension
