基本説明
Provides current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience and neuroradiology.
Full Description
Nanoneuroscience, nanoneurosurgery, and nanobioelectronics have the potential to revolutionize medicine and improve the prevention, diagnosis, and treatment of neurological disorders over the next 10-20 years. The Textbook of Nanoneuroscience and Nanoneurosurgery presents a state-of-the-art review of the field, providing current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience, and neuroradiology.The text also reviews the latest regulatory guidelines that influence the translation of nanotechnological research from the laboratory to the clinic, as well as the most recent information on biodevices and pharmaceutical spinoffs. It highlights presidential and congressional initiatives and programs that may significantly impact the field in the near future. Chapters discuss the latest science and technologies-which are applied to diagnosis and treatment of neurological disorders-as well as regulatory issues that impact product development.This volume describes advances that have already been translated to the clinic or hold significant promise for future application in nanoneurosurgery, as well as their potential impact. A full-color text, the book contains contributions by more than 120 researchers, original and descriptive illustrations, and more than 3,000 references. Offering broad coverage of nanotechnological applications in diverse areas and addressing FDA regulation and healthcare policy, this volume provides a foundation of ideas and methods for scientists and physicians to devise successful, less invasive procedures for future treatment of nervous system disorders.
Contents
Chapter 1From Nanotechnology to Nanoneuroscience/Nanoneurosurgery and Nanobioelectronics: A Historical Review of MilestonesVicky Yamamoto, Giancarlo Suffredini, Shouleh Nikzad, Michael E. Hoenk, Miriam S. Boer, Charlie Teo, John D. Heiss, and Babak KatebChapter 2:Nanoneurology and NanoneurosurgeryGeoffrey S. F. Ling, Robbin Miranda, and Gill PrattChapter 3:Nanopolymers and Nanoconjugates for Central Nervous System Diagnostics and TherapiesGiancarlo Suffredini and Lucien M. LevyChapter 4:Micelles and Liposomes: Lipid Nanovehicles for Intracerebral Drug DeliveryMassimo S. Fiandaca and Krystof S. BankiewiczChapter 5:Peptide and Protein-Based NanoparticlesAyaz M. Khawaja and John D. HeissChapter 6:Endohedral Metallofullerenes, Iron Oxide Agents, and Gold Nanoparticles for Brain ImagingMartina A. McAteer and Robin P. ChoudhuryChapter 7:Carbon Nanoplatforms and Their Application for Neurological DisordersHouman Badrzadeh, Peyman Tashkandi, Michelle Knosp, and Babak KatebChapter 8:DendrimersAyaz M. Khawaja and John D. HeissChapter 9:Ligand-Based Targeting of Therapeutic and Imaging Agents for CancerQimeng Quan, Seulki Lee, and Xiaoyuan ChenChapter 10:Immune-Based Targeting in CancerDwain K. Irvin, Chirag G. Patil, and Keith L. BlackChapter 11:Directed Drug Convection Using Magnetic Nanoparticles as Therapeutic Carriers: Meeting the Challenge of Specific Brain Pharmacotherapeutics, Non-Ligand-Based Central Nervous System Targeting, Including Magnetic FocusingDavid F. Moore, Vinith Yathindranath, Torsten Hegmann, Donald Miller, Marc Pelletier, and Raphael SchiffmannChapter 12:Intralesional and Intraparenchymal Convection-Enhanced Delivery of NanoparticlesTatsuhiro Fujii, Daniel Angeles, Li-Chen Hsu, Rahul Jandial, and Mike ChenChapter 13:Transport of Nanoparticles across Blood-Brain BarrierRobert T. Wicks, Zev A. Binder, and Alessandro OliviChapter 14:Nanomedicine Treatment Strategies That Exploit Unique Characteristics of Tumor Vasculature and MicroenvironmentJun Wu, Tats Fujii, and Mike Y. ChenChapter 15:Focused Ultrasound for Noninvasive NeuromodulationMartin O. Culjat, Richard E. Fan, Meghedi Babakhanian, Amit P. Mulgaonkar, Rahul S. Singh, Warren S. Grundfest, and William P. MelegaChapter 16:NanosensorsJ. Matthew Dubach and Heather A. ClarkChapter 17:Implantable Infusion Pumps Incorporating NanotechnologyEllis Meng, Tuan Hoang, and Uttam SinhaChapter 18:Nanostructured Surfaces for Intracerebral Neurotransmitter RecordingDavid A. Price, Artin Petrossians, Pooja M. Talauliker, Francois Pomerleau, Peter Huettl, Florian Mansfeld, James Weiland, J. Todd Hastings, and Greg A. GerhardtChapter 19:Therapy for Neuronopathic Lysosomal Storage DiseasesAyaz M. Khawaja, John D. Heiss, and Roscoe O. BradyChapter 20:Nanotechnology for Cerebral Aneurysm TreatmentJean Paul Allain, Teodoro Tigno, and Rocco ArmondaChapter 21:Improving Treatment of Stroke through NanotechnologyFrancesca Nicholls, Natalia Gorenkova, Ellen Bible, Christy Franco, David Chau, Christos Tolias, Kevin Shakesheff, Jennifer West, and Michel ModoChapter 22:Molecular Medical Devices for NanoneurosurgeryRutledge Ellis-BehnkeChapter 23:Applications of Nanotechnology in EpilepsyPaul R. CarneyChapter 24:Applications of Nanotechnology to Diseases of the SpineBryn S. Moore and Steven A. TomsChapter 25:Nanoparticle-Based Treatment and Imaging of Brain Tumors: Potentials and LimitationsBong-Seop Lee, Christopher J. Hanson, Rina Amatya, Esther Chung, Mansur Ghani, Allen Yen, Keith L. Black, and John S. YuChapter 26:Tumor-Targeted Nanodrugs for Treatment of Primary Brain TumorsJoseph Cheatle and Michele AizenbergChapter 27:Application of Nanotechnology in the Diagnosis and Treatment of Brain MetastasisJoel C. Sunshine, Zachary D. Guss, Jay J. Pillai, and Michael LimChapter 28:Nanotechnology in Extra-Axial and Pituitary TumorsAimee Two, J. Peter Gruen, and Gabriel ZadaChapter 29:Using Nanoparticles in Diagnosis and Treatment of CNS InfectionZion Zibly, Cody D. Schlaff, and John D. HeissChapter 30:Applications of Nanotechnology in Movement DisordersPatrick Pezeshkian, Karlo J. Lizarraga, Alessandra Gorgulho, and Antonio De SallesChapter 31:Nanomedicine in Demyelinating Disease: Application to Diagnosis and Therapy in Multiple SclerosisEmily C. Leibovitch and Steven JacobsonChapter 32:Applications of Nanotechnology in Degenerative Disorders of the BrainAyaz M. Khawaja and John D. HeissChapter 33:Brain-Machine Interface and RehabilitationMartin Pham, Alexander Taghva, and Ali R. RezaiChapter 34:Nanobioelectronics for Noninvasive Neuronal TherapyEvangelia Hondroulis, Jairo Nelson, and Chen-Zhong LiChapter 35:In Vitro and In Vivo Techniques to Assess Neurotoxicity of NanoparticlesThomas Birngruber, Eleonore Froehlich, Frank Sinner, and Thomas PieberChapter 36:Nanorobotics for NeurosurgeryRobbin Miranda, Gill Pratt, and Geoffrey S. F. LingChapter 37:Imaging and Tracking Therapeutic Cells with NanoparticlesGang Niu and Joseph A. FrankChapter 38:Micro- and Nanotechnology in Nerve RepairAli C. Ravanpay and Michel KliotChapter 39:Nanotechnology: Applications to Pediatric NeurosurgeryGiancarlo Suffredini and Robert F. KeatingChapter 40:Food and Drug Administration Regulatory Framework for Nanodrugs and Nanodevices and the Combination NanodrugVicky Yamamoto, Giancarlo Suffredini, John D. Heiss, David Mishelevich, Grant Palmer, Warren Grundfest, and Babak KatebChapter 41:Nanoneuroscience and Nanoneurosurgery: A Key Component of President Obama's Brain Mapping InitiativeBabak Kateb, Vicky Yamamoto, Peter Basser, Michael Roy, Lucien Levy, Jian Tajbakhsh, Gary Steinberg, Allyson Rosen, Keith L. Black, Charlie Teo, Kuldip Sidhu, Mitchel Berger, and Warren Grundfest
