基本説明
初版が1966年に刊行された、この領域におけるリーディング・タイトルの６年ぶりの改訂版。難病とされる全身性エリテマトーデスとその関連症候群について詳述な新知見を提供。
Prev. ed.: 2006 by LWW.
Full Description
Recognized for more than 45 years as the definitive text in the field, Dubois' Lupus Erythematosus and Related Syndromes strikes the perfect balance between basic science and clinical expertise, providing the evidence-based findings, treatment consensuses, and practical clinical information you need to confidently diagnose and manage SLE. Broaden your understanding with comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes fundamental images of lupus rashes as well as graphs, algorithms, and differential diagnosis comparisons.Discover the latest in systemic lupus erythematosus with new chapters on important emerging topics such as socioeconomic and disability aspects; and rigorously updated chapters that include expanded coverage of the nervous system, and the most in-depth discussion of immunity and regulatory cells.Learn from the very best. World-renowned rheumatologists Drs. Daniel Wallace and Bevra Hannahs Hahn, along with new associate editors Drs. Michael Weisman, Ronald Van Vollenhoven, Nan Shen, and David Isenberg, present definitive coverage on new and rapidly changing areas in the field.Rely on it anytime, anywhere! Access the full text, image bank, and bonus online-only chapters at www.expertconsult.com.Dubois' Lupus Erythematosus was first published in 1966. For the past forty years, the product has distinguished itself internationally as the go-to reference on lupus and related diseases.For rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on systemic lupus erythematosus (SLE) and related disorders, this product delivers a complete arsenal of information on SLE, connective tissue diseases, and the antiphospholipid syndromes.
Contents
Section I1. Definition and classification of Lupus and Lupus-Related Disorders2. The Epidemiology of LupusSection II: The Pathogenesis of Lupus3. The Pathogenesis of SLE4. Genetics of Human SLE5. Epigenetics of Lupus6. The Innate Immune System in SLE7. Cytokines and Interferons in Lupus8. The Structure and Derivation of Antibodies and Autoantibodies9. T Cells10. Regulatory Cells in SLE11. Apoptosis, Necrosis, and Autophagy12. Abnormalities in Immune Complex Clearance and Fc? Receptor Function13. Neural-Immune Interactions: Principles and Relevance to SLE14. Complement and SLE15. Mechanisms of Acute Inflammation and Vascular Injury in SLE16. Mechanisms of Tissue Damage - Free Radicals and Fibrosis17. Animal Models of SLE18. Pathogenic Mechanisms in Lupus NephritisSection III: Autoantibodies19. Immune Tolerance Defects in Lupus20. Autoantibodies21. Autoantigenesis and Entigen-Based Therapy and Vaccination in SLESection IV: Clinical Aspects of SLE22. Overview and Clinical Presentation23. Pathomechanisms of Cutaneous Lupus Erythematosus24. Skin Disease in Cutaneous Lupus Erythematosus25. The Musculoskeletal System and Bone Metabolism26. Pathogenesis and Treatment of Atherosclerosis in Lupus27. Cardiopulmonary Disease in SLE28. Pathogenesis of the Nervous System29. Clinical Aspects of the Nervous System30. Psychopathology, Neurodiagnostic Testing, and Imaging31. Ocular, Aural, and Oral Manifestations32. Management of Sj gren Syndrome in Patients with SLE33. Gastrointestinal and Hepatic Manifestations34. Hematologic and Lymphoid Abnormalities in SLE35. Clinical and Epidemiologic Features of Lupus NephritisSection V: The Reproductive System & Hormones36. Pregnancy in Women with SLE37. Neonatal Lupus Erythematosus38. Reproductive and Hormonal Issues in Women with Autoimmune DiseasesSection VI: Special Considerations, Subsets of SLE and Lupus-Related Syndromes39. Drug-Induced Lupus: Etiology, Pathogenesis, and Clinical Aspects40. SLE in Childhood and Adolescence41. Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease42. Clinical Aspects of the Antiphospholipid SyndromeSection VII: Assessment of Lupus43. Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Clinical Laboratory Tests in SLE44. Differential Diagnosis and Disease Associations45. SLE and Infections46. Clinical Measures, Metrics and IndicesSection VIII: Management of SLE47. Principles of Therapy, Local Measures, Nonsteroidal Medications48. Systemic Glucocorticoid Therapy in SLE49. Antimalarial Medications50. Immunosuppressive Drug Therapy51. Specialized Treatment Approaches and Niche Therapies for Lupus Subsets52. Adjunctive and Preventive Measures 53. Novel Therapies for SLE: Biological Agents Available in Practice Today54. Critical Issues in Drug Development for SLE55. Socioeconomic and Disability AspectsSection IX: Outcomes and Future Considerations56. Investigational Agents and Future Therapy for SLE57. Mortality in SLE Appendix: Lupus Resource MaterialsIndex
